Communications
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A comprehensive analysis of autophagy related signatures in cancer (Id30)
Guerra-Andrés, M.1,2, García López, I. 1 & F. Fernández, Á.1,2,3
1 Department of Biochemistry and Molecular Biology University of Oviedo, Oviedo, Asturias.
2 University Institute of Oncology of Asturias (IUOPA), Oviedo, Asturias.
3 Sanitary Research Institute of Asturias (ISPA), Oviedo, Asturias.
AMBRA1 regulates the generation and progression of squamous cell carcinomas (Id45)
Gabicagogeascoa E1,2 ,Lorente M1,2, Stefanos N3,4, Salvador N1,2, Saiz-Ladera C1,2, Hill D4, Salazar-Roa M1,2, Martín-Cabrera P1,2, Alexander, M3, Orea-Soufi A1,2, García-Taboada E1,2, Boya P5, Herrera B6, Sánchez-Muñoz A6, Lovat P4 and Velasco G1,2
1 Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
2 Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain.
3 Addenbrookes Hospital, Cambridge, United Kingdom.
4 Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
5 Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
6 Department of Biochemistry and Molecular Biology, School of Pharmacy, Complutense University, Madrid, Spain.
Analysis of the Dictyostelium discoideum TipC protein role in autophagy (Id15)
Antón-Esteban L, Roque-Guerra AS, Vincent O and Escalante R
Instituto de Investigaciones Biomédicas Sols-Morreale CSIC-UAM, Madrid, Spain.
Analysis of the interaction of human WIPI proteins with ATG2 (Id17)
Fernández M1, Pascual A1, Escalante R2, Vincent O2 and Navas MA1
1 Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, UCM, Madrid, Spain
2 Instituto de Investigaciones Biomédicas Sols-Morreale CSIC-UAM, Madrid, Spain.
Autophagy perturbations in a myotonic dystrophy type 1 in vitro model (Id7)
Giménez-Bejarano A1,2,3, Alegre-Cortés E1,2,3, Ojalvo-Pacheco J1, Paredes-Barquero M1,2,3 , González-Polo RA1,2,3, Canales-Cortés S1,2,3, Blanco-Benítez M1,2,3, Domínguez-Rojo N1,2,3, Niso-Santano M1,2,3, Yakhine-Diop SMS1,2,3, Fuentes JM1,2,3, Gómez-Suaga P1,2,3
1 Universidad de Extremadura. Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y TO,10003 Cáceres, Spain.
2 Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativa, Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain.
3 Instituto de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain. Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain.
Chaperone-mediated autophagy is a cytoprotective response of photoreceptors during aging and retinal diseases (Id39)
Gómez-Sintes, R1,2, Tasset-Cuevas, I2, Cuervo, AM2,3, Boya, P1.
1 Departmento de Biología Celular y Molecular, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
2 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY.
3 Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY.
Deciphering the role of ORMDL3 in THC-induced autophagy: potential implications for glioblastoma therapy (Id44)
Martínez-Martínez E1, Cordani, M, Santos A1, Moraleda-Esteban R1, García-López R2, Castillo-Lluva S1, Tovar-Ambel E1, Orea-Soufi A1, Antonioli M3, Lorente M1, Fimia GM3, Hernández-Tiedra S1, Vicente R2, and G. Velasco1
1 Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University and Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.
2 Molecular Physiology Group, Pompeu Fabra University, Barcelona, Spain.
3 Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, IRCCS, Rome, Italy.
Deregulation of autophagic flux in ALMS1 protein-dependent ciliopathic models (Id24)
Fernández Pereira, A.G; Corral Nieto, Y.; Bravo San Pedro, JM
Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología. Madrid.
Drug repurposing to tackle Crohn’s disease progression: Screening of a FDA-approved drug library against TNF-α-driven cell death in autophagy-deficient genetic models (Id49)
Valero Cortijo, A.1, 2; Shoenenberger, J.A.1, 2, 3; Yuste, V.J.4,5, Ribas, J.1,2
1 Pharmacoepidemiology & Pharmacodynamics Group, [Lleida Institute for Biomedical Research Dr. Pifarré Foundation] IRBLLeida, Lleida, Spain.
2 Department of Experimental Medicine, University of Lleida, Lleida, Spain.
3 Hospital Universitari Arnau de Vilanova de Lleida – ICS, Lleida, Spain.
4 Cell Death, Senescence and Survival Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain.
5 Institute of Neurosciences, Autonomous University of Barcelona, Barcelona, Spain.
Elucidating the role of autophagy activity in LRRK2-PD iPSC derived microglia in the pathogenesis of Parkinson’s disease (Id27)
Scrivo A.1, Testa V.1, Baruffi V.1, Fernandez Carasa I.1, Raya A.2,3,4, Consiglio A.1,5
1 Department of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, 08908 Hospitalet de Llobregat, Spain; Institute of Biomedicine (IBUB) of the University of Barcelona (UB), Barcelona, Spain.
2 Stem Cell Potency Lab, Regenerative Medicine Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Hospitalet de Llobregat, 08908 Barcelona, Spain.
3 Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
4 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
5 Department of Molecular and Translational Medicine, University of Brescia, Brescia BS, Italy.
Induction of mitophagy by acorn cupule extract . Mechanisms involved (Id36)
Domínguez-Rojo N.1,2*; Blanco-Benítez M.1,2,3*; Canales-Cortés S.1,2,3; Alegre-Cortés E.1,2,3; Paredes-Barquero M.2; Ojalvo-Pacheco J.1; Giménez-Bejarano A1,2,3 Uribe-Carretero E. 1,2,3 Lavado G.4; Hernández-Eguiazu Haizea5; Moragón Saioa5; Gereñu Gorka5; Camello P.J.4;Niso-Santano M.1,2,3; Gómez-Suaga P1,2,3;Yakhine Diop S.M.S.1,2,3; Cava R4; Fuentes JM1,2,3; González-Polo R.A.1,2,3
1 Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Spain;
2 Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain; 3 Centro de Investigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Spain;
4 Universidad de Extremadura, INBio G-C, Departamento Facultad de Veterinaria, Cáceres, Spain.
5 Instituto Biodonostia, 20014 San Sebastian.
6 Universidad de Extremadura, Departamento de Fisiología, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain.
Inhibition of the SUMO machinery in cancer-associated fibroblasts has a dual role in breast cancer progression (Id40)
Angélica Martínez-López1,2 Guiomar Infante1,2, Mónica González-Fernández1,2, Olga M. Antón1,2, Marina Mendiburu-Eliçabe1, Andrés Machuca-Marcos3, José L. Luque-García3, Sonia Castillo-Lluva1,2
1 Departamento de Bioquímica y Biología Molecular. Facultad de Química. Universidad Complutense de Madrid. Madrid, España.
2 Fundación para la Investigación Biomédica del Hospital Clínico San Carlos (FIBHCSC). Madrid, España.
3 Departamento de Química Analítica. Facultad de Química. Universidad Complutense de Madrid. Madrid, España.
Involvement of Queen Bee Acid in the removal of protein aggregates (Id32)
Paredes-Barquero M.1,2,3, Canales-Cortés S.1,2,3, Alegre-Cortés E.1,2,3, Giménez-Bejarano A.1,2,3, Blanco-Benítez M.1,2,3, Domínguez-Rojo N.1,2, Ojalvo-Pacheco J.1,Santos-Galindo M.3,4, Gómez-Suaga P.1,2, Yakhine-Diop S.M.S1,2,3, González-PoloR.A.1,2,3, Pietrocola F.5, Lucas J.J.3,4 , Fuentes J.M.1,2,3 , Niso-Santano M.1,2,3
1 Universidad de Extremadura. Departamento de Bioquímica y Biología Molecular yGenética, Facultad de Enfermería y Terapia Ocupacional, 10003 Cáceres, Spain.
2 Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 10003Cáceres, Spain.
3 Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain.
4 Centro de Biología Molecular 'Severo Ochoa' (CBMSO), Centro Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid (UAM), Madrid, Spain.
5 Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
Lysosomal Dysfunction: Connecting the Dots in the Landscape of Human Diseases (Id23)
Uribe-Carretero E.1,2,3, Rey V.4, Yakhine-Diop S.M.S.1,2,3, Ojalvo-Pacheco J.1,3, Dominguez-Rojo N.1,3, Carretero-Morán E.5, Fuentes J.M.1,2,3, Tamargo-Gómez I.4
1 Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Caceres, Spain.
2 Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativa, Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), Madrid, Spain.
3 Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Caceres, Spain
4 Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
5 Achucarro Basque Center for Neuroscience, Bizkaia, Spain.
Mitophagy de regulation in repeat expansion diseases (Id33)
Giménez-Bejarano, A.1,2,3, Ojalvo-Pacheco, J.1,2, Alegre-Cortés, E.1,2,3, Canales-Cortés, S.1,2,3, Paredes-Barquero, M.2,3, Blanco-Benítez, M.1,2,3, Domínguez-Rojo, N.1,2, Niso-Santano, M.1,2,3, González-Polo, R.A.1,2,3, Yakhine-Diop, S.M.S.1,2,3, Fuentes, J.1,2,3, Gómez-Suaga, P. 1,2,3
1 Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Cáceres, Spain.
2 Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Cáceres, Spain.
3 Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Comunidad de Madrid, Spain.
Modulator of the mTOR Pathway: Implication for Autophagic Regulation (Id37)
Canales-Cortés, S.1,2,3; Domínguez-Rojo, N.1,2; Blanco-Benítez, M.1,2,3; Paredes-Barquero, M.1,2,3; Alegre-Cortés, E.1,2,3; Giménez-Bejarano, A.1,2,3; Ojalvo-Pacheco, J.1; Gómez-Suaga, P.1,2,3; Yakhine-Diop, S.M.S.1,2,3; Niso-Santano, M.1,2,3; Fuentes, J.M.1,2,3; González-Polo, R.1,2,3.
1 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura;
2 Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE);
3 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED).
Molecular mechanisms underlying the neuroprotective effects of elderflower (Id35)
García-Aguilar, A1,2, Cetani, A.M.1, Goya Suárez L3, Guillén, C2,4, Palomino O.M.1,2
1 Department of Pharmacology, Pharmacognosy and Botany, School of Pharmacy, University Complutense of Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
2 Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Instituto de Salud Carlos III (IdISSC), 28029 Madrid, Spain.
3 Department of Metabolism and Nutrition, Institute of Science and Food Technology and Nutrition (ICTAN—CSIC), 28040 Madrid, Spain.
4 Department of Biochemistry and Molecular Biology, School of Pharmacy, University Complutense of Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain; IdISSC, Madrid, Spain.
NanoGBA-to-brain strategy as a novel Parkinson’s disease treatment (Id22)
Castillo-Sánchez P.1, Pradas E.1, 2, Arrúe-Gonzalez M.1, Tanco S.2, Sarlé-Vallé P.2, Montpeyo D.2, Basanta N.2, Conejero I.3, Riera J.1, Montpeyo M.1, Navarro-Romero A.1, Carnicer-Cáceres C4, Arranz-Amo JA.4, Castillo-Ribelles L.4, Novio F.2, Vicent MJ.3, Lorenzo Rivera J.2, Martinez-Vicente M.1
1 Neurodegenerative diseases group. Vall d’Hebron Research Institute (VHIR).
2 Protein Engineering and Nanomedicine group. Universitat Autònoma de Barcelona (UAB).
3 Polymer Therapeutics Lab. Centro de investigación Principe Felipe (CIPF).
4 Biochemistry Service, Vall d’Hebron Hospital.
RASSF2 is a novel autophagy regulator with potential implications on cellular homeostasis and aging (Id26)
Manastireanu, D1, Salazar Martinez, N1, Ponce-Mora, A1, Domenech Bendaña, A1, Barragán Martín, I1, Quereda, JJ2, Bejarano, E1, Landeras-Bueno, S1, Nieto-Torres, JL1
1 Department of Biomedical Sciences, School of Health Sciences and Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
2 Department of Animal Production and Health, Veterinary Public Health and Food Science and Technology, Faculty of Veterinary Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Role of the glycogen-related protein malin in glycophagy (Id9)
Pasquale Pellegrini1, Joan J. Guinovart1, Jordi Duran2
1 Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028 Barcelona
2 Institut Químic de Sarrià (IQS), Universitat Ramon Llull (URL), 08017 Barcelona
3 Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona.
Study of autophagy to provide novel CIN-targeted therapy in breast cancer (Id16)
Bosch-Calvet M1,2, Greoles-Cano J1, Garcia-Cajide M1,2, Mauvezin C1,2
1 Department of Biomedicine, Faculty of Medicine and Health Sciences, University of Barcelona, Catalonia, Spain.
2 August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Catalonia, Spain.
Taurine boots autophagy and ameliorates glycative-stress derived damage (Id4)
Nicolle Andrea Salazar Martinez1, Alejandro Ponce-Mora1, Jesus Alarcón-Gil2, Andrea Yuste1, Alicia Doménech-Bendaña1, María José Asensio-Vegas2, Marta Posada-Gracia2, Cristina Trujillo-Del Río3, Lucia Gimeno-Mallench1, Antonella Locascio1, Rafael Vázquez-Manrique3, José Antonio Rodríguez-Navarro4 and Eloy Bejarano1
1 Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain;
2 Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain;
3 Laboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, Valencia, Spain;
4 Departamento Biología Celular, Universidad Complutense Madrid, Madrid, Spain.
The antioxidant properties of 3-methyladenine mediate its antiapoptotic action independently of the autophagy flux inhibition (Id50)
Beà, A.1, 2; Martínez-Escardó, L.5, 6; Valero Cortijo, A.1, 2; Perramon, A.4 ; Chicote, J.1, 2; Encinas, M.4 ; Shoenenberger, J.A.1, 2, 3; Yuste, V.J.4,5 ; Ribas, J.1,2
1 Pharmacoepidemiology & Pharmacodynamics Group, [Lleida Institute for Biomedical Research Dr. Pifarré Foundation] IRBLLeida, Lleida, Spain.
2 Department of Experimental Medicine, University of Lleida, Lleida, Spain.
3 Hospital Universitari Arnau de Vilanova de Lleida – ICS, Lleida, Spain.
4 Oncogenic Signalling and Development, Department of Experimental Medicine, University of Lleida-IRBLleida, Lleida, Spain.
5 Cell Death, Senescence and Survival Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain.
6 Institute of Neurosciences, Autonomous University of Barcelona, Barcelona, Spain.
The role of ACBP in ciliopathy-derived obesity (Id25)
Corral Nieto, Y.; Fernández Pereira, A.G.; Bravo San Pedro, JM
Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología. Madrid
Unraveling the role of SQSTM1 in mitosis: Insights and Implications (Id41)
Ilidaki M1*, Romanovic K1*, Garcia-Cajide M1,2, Mauvezin C1,2.
1 Department of Biomedicine, Faculty of Medicine and Health Sciences, University of Barcelona, Catalonia, Spain.
2 August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Catalonia, Spain.
* first-co-authors