Comunicaciones Póster / Poster communications
* E-Poster
Symposium 1: “Stem Cells”
Chairs:
Colin R. Goding. Ludwig Institute for Cancer Research (LICR). Oxford. UK
Pedro Fernández. Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE). Universidad de Extremadura. Badajoz. Spain
Colin R. Goding. Ludwig Institute for Cancer Research (LICR). Oxford. UK
Pedro Fernández. Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE). Universidad de Extremadura. Badajoz. Spain
BROC2: A new human cell line to study the airway epithelium g (ID_40)
Selene Diaz-Chamorro, Juan Francisco Barrera-Lopez, Guadalupe Cumplido-Laso, Clara Maria Mateos-Quiros, Sergio Garrido-Jimenez, Angel Carlos Roman, Francisco Centeno and Jose Maria Carvajal-Gonzalez
Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06071-Badajoz, Spain.
Selene Diaz-Chamorro, Juan Francisco Barrera-Lopez, Guadalupe Cumplido-Laso, Clara Maria Mateos-Quiros, Sergio Garrido-Jimenez, Angel Carlos Roman, Francisco Centeno and Jose Maria Carvajal-Gonzalez
Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06071-Badajoz, Spain.
Colon cancer patient-derived organoids as a platform for personalized antitumoral drug testing (ID_3)
Bustamante-Madrid P1,2, Costales-Carrera A1,2, Fernández-Barral A1,2, Rodríguez-Cobos J1, Barbáchano A1,2 and Muñoz A1,2 1 Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Madrid; 2 CIBERONC, Madrid
Bustamante-Madrid P1,2, Costales-Carrera A1,2, Fernández-Barral A1,2, Rodríguez-Cobos J1, Barbáchano A1,2 and Muñoz A1,2 1 Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Madrid; 2 CIBERONC, Madrid
*Contribution of undifferentiated cells to metastasis in Neuroblastoma (ID_10)
Amador-Álvarez A (1)(2), Gómez-Muñoz M.A (1)(3), Pardal R (1)(3), Vega F.M (1)(2)
(1) Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; (2) Departamento de Biología Celular, Universidad de Sevilla, Seville, Spain; (3) Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Seville, Spain
Amador-Álvarez A (1)(2), Gómez-Muñoz M.A (1)(3), Pardal R (1)(3), Vega F.M (1)(2)
(1) Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; (2) Departamento de Biología Celular, Universidad de Sevilla, Seville, Spain; (3) Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Seville, Spain
Disruption of TAp73 isoform by CRISPR-Cas9-mediated gene editing in mouse embryonic stem cells reveals alterations in adhesion gene networks (ID_38)
Martínez-García N. 1,2, Maeso-Alonso L. 1,3, López-Ferreras L. 1,3, Martín-López M. 1,4, Díez-Matilla A. 1, Villoch-Fernandez J. 1,3, Alonso-Olivares H. 1,3, Marques M. M. 2,5 and Marin M. C. 1,3
1Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain; 2Departamento de Producción Animal, Universidad de León, 24071 León, Spain; 3Departamento de Biología Molecular, Universidad de León, 24071 León, Spain; 4Biomar Microbial Technologies, Parque Tecnológico de León, Armunia, 24009 León, Spain; 5Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, 24071 León, Spain.
Martínez-García N. 1,2, Maeso-Alonso L. 1,3, López-Ferreras L. 1,3, Martín-López M. 1,4, Díez-Matilla A. 1, Villoch-Fernandez J. 1,3, Alonso-Olivares H. 1,3, Marques M. M. 2,5 and Marin M. C. 1,3
1Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain; 2Departamento de Producción Animal, Universidad de León, 24071 León, Spain; 3Departamento de Biología Molecular, Universidad de León, 24071 León, Spain; 4Biomar Microbial Technologies, Parque Tecnológico de León, Armunia, 24009 León, Spain; 5Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, 24071 León, Spain.
*Protein convertase 9 in colorrectal cáncer stem cells (ID_104)
Garcia-Gallstegi P., Martin A., Unda F., Badiola I.
Departament of Cell Biology and HIstology, Faculty of Medicine and Nursing. Leioa/ Biscay. Spain
Garcia-Gallstegi P., Martin A., Unda F., Badiola I.
Departament of Cell Biology and HIstology, Faculty of Medicine and Nursing. Leioa/ Biscay. Spain
RELATIONSHIP BETWEEN THE PRESENCE OF MELANOCYTES AND THE PRESERVATION OF THE UNDIFFERENTIATED PHENOTYPE OF THE CORNEAL EPITHELIAL STEM/PROGENITOR CELLS IN HUMAN CELL CULTURES (ID_74)
Romo-Valera C1, Pérez-Garrastachu M1, Rodriguez-Astigarraga M1, Arluzea J1, Boyano MD1,2, Andollo N1,2
1Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country, Sarriena, S/N, 48940 Leioa, Spain; 2Biocruces Bizkaia Health Research Institute, Cruces Plaza S/N, 48903 Barakaldo, Spain
Romo-Valera C1, Pérez-Garrastachu M1, Rodriguez-Astigarraga M1, Arluzea J1, Boyano MD1,2, Andollo N1,2
1Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country, Sarriena, S/N, 48940 Leioa, Spain; 2Biocruces Bizkaia Health Research Institute, Cruces Plaza S/N, 48903 Barakaldo, Spain
Role of TRIB3 pseudokinase in luminal breast cancer (ID_78)
Alba Orea-Soufi1,2, Mar Lorente1,2, Sonia Castillo Lluva1,2, Paola Martín-Cabrera1, Silvia Recuero1, Elena García-Taboada1, Nélida Salvador-Tormo1,2, Manuel Moreno-Valladares3, Estíbaliz Gabicagogeascoa1,2, Marina Mendiburu Eliçabe1,4, Adrián Blanco-Gómez5, Maria Salazar-Roa1, Ana García-Casas1,2, Angélica Martínez1,2, Ander Matheu5, Isabel M Álvarez-López3, Guillermo Velasco
1 Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain, 2 Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain; 3Hospital Universitario Donostia, Donostia, Spain; 4Universidad de Salamanc, Salamnca, Spain; 5IIS Biodonostia, Donostia, Spain
Alba Orea-Soufi1,2, Mar Lorente1,2, Sonia Castillo Lluva1,2, Paola Martín-Cabrera1, Silvia Recuero1, Elena García-Taboada1, Nélida Salvador-Tormo1,2, Manuel Moreno-Valladares3, Estíbaliz Gabicagogeascoa1,2, Marina Mendiburu Eliçabe1,4, Adrián Blanco-Gómez5, Maria Salazar-Roa1, Ana García-Casas1,2, Angélica Martínez1,2, Ander Matheu5, Isabel M Álvarez-López3, Guillermo Velasco
1 Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain, 2 Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain; 3Hospital Universitario Donostia, Donostia, Spain; 4Universidad de Salamanc, Salamnca, Spain; 5IIS Biodonostia, Donostia, Spain
*Systemic but not intra-articular infusion of human adipose-derived mesenchymal stromal cells (hAD-MSCs) attenuates acute arthritis flare in a rabbit model (ID_36)
Medina JP*1, Bermejo Álvarez I1, Yáñez R2, Fernández-García M2, García-Olmo D3, Bueren J2, Herrero-Beaumont G1, Largo R1.
1Bone and Joint Research Unit, Rheumatology Department, IIS-Fundación Jiménez Díaz, Madrid, Spain; 2Hematopoietic Innovative Therapies Division. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain. IIS- Fundación Jiménez Díaz UAM, Madrid, Spain; 3New Therapies Laboratory, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain. Department of Surgery, Fundación Jiménez Díaz University Hospital, Madrid, Spain. Department of Surgery, School of Medicine UAM, Madrid, Spain.
Medina JP*1, Bermejo Álvarez I1, Yáñez R2, Fernández-García M2, García-Olmo D3, Bueren J2, Herrero-Beaumont G1, Largo R1.
1Bone and Joint Research Unit, Rheumatology Department, IIS-Fundación Jiménez Díaz, Madrid, Spain; 2Hematopoietic Innovative Therapies Division. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain. IIS- Fundación Jiménez Díaz UAM, Madrid, Spain; 3New Therapies Laboratory, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain. Department of Surgery, Fundación Jiménez Díaz University Hospital, Madrid, Spain. Department of Surgery, School of Medicine UAM, Madrid, Spain.
Vitamin D modulates cell phenotype and proliferation in human colon organoids (ID_2)
Bustamante-Madrid P1,2, Fernández-Barral A1,2, Albandea-Rodríguez D1,2, Larriba MJ1,2, Muñoz A1,2, Lafarga M3, and Barbáchano A1,2
1 Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Madrid; 2 CIBERONC, Madrid 3 University of Cantabria-IDIVAL, Santander
Bustamante-Madrid P1,2, Fernández-Barral A1,2, Albandea-Rodríguez D1,2, Larriba MJ1,2, Muñoz A1,2, Lafarga M3, and Barbáchano A1,2
1 Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Madrid; 2 CIBERONC, Madrid 3 University of Cantabria-IDIVAL, Santander
Symposium 2: “Cell differentiation and reprogramming”
Chairs:
Carmen Marín. Universidad de León (ULE). León. Spain
Manuel Reina. Universitat de Barcelona. Barcelona. Spain
Carmen Marín. Universidad de León (ULE). León. Spain
Manuel Reina. Universitat de Barcelona. Barcelona. Spain
*DLK1, an inhibitory non-canonical ligand of NOTCH receptors, inhibits osteoblastic differentiation of pre-osteoblastic MC3T3-E1 cell line. (ID_95)
González-Gómez, M.J.1, Rodríguez-Cano, M 2, Resuela-González, J.L.2, Nueda, M.L 2, Laborda, J.2, and Baladrón, V 3.
Laboratory of Biochemistry and Molecular Biology, Department of Inorganic and Organic Chemistry and Biochemistry, Higher Technical School of Agricultural and Forestry Engineering 1/ Pharmacy School 2/ Medical School 3/ Regional Biomedical Research Center (CRIB)/ Biomedicine Unit, UCLM/CSIC. Albacete, Spain.
González-Gómez, M.J.1, Rodríguez-Cano, M 2, Resuela-González, J.L.2, Nueda, M.L 2, Laborda, J.2, and Baladrón, V 3.
Laboratory of Biochemistry and Molecular Biology, Department of Inorganic and Organic Chemistry and Biochemistry, Higher Technical School of Agricultural and Forestry Engineering 1/ Pharmacy School 2/ Medical School 3/ Regional Biomedical Research Center (CRIB)/ Biomedicine Unit, UCLM/CSIC. Albacete, Spain.
In vitro exposure of myoblasts to bisphenol A impairs their differentiation towards cardiomyocytes (ID_1)
Marta Lombó1, Enrique Escarda-Castro2, María Paz Herráez3
1Departamento de Reproducción Animal, INIA, Madrid España; 2MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht, Países Bajos; 3Departamento de Biología Molecular, León, España
Inhibitors of mammalian kinase GSK-3β promote cell reprogramming and in vitro embryogenesis in plants (ID_83)
Pérez-Pérez Y 1, Berenguer E 1, Carneros E 1, Gil C 2, Martínez A 2, Testillano PS 1
1Pollen Biotechnology of Crop Plants group, Center of Biological Research Margarita Salas, CIB-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain. 2Translational Medicinal and Biological Chemistry group, Center of Biological Research Margarita Salas, CIB-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
Pérez-Pérez Y 1, Berenguer E 1, Carneros E 1, Gil C 2, Martínez A 2, Testillano PS 1
1Pollen Biotechnology of Crop Plants group, Center of Biological Research Margarita Salas, CIB-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain. 2Translational Medicinal and Biological Chemistry group, Center of Biological Research Margarita Salas, CIB-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
Junctional adhesion molecule 3 expression in the mouse airway epithelium is linked to multiciliated cells (ID_44)
Mateos-Quiros, C.M.1, Garrido-Jimenez, S.1, Álvarez-Hernán, G.2, Diaz-Chamorro, S.1, Barrera-Lopez, J.F.1, Morcillo, F.J.2, Roman, A.C.1, Centeno, F.1 and Carvajal-Gonzalez, J.M. 1
1-Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06071-Badajoz, Spain. 2-Área de Biología Celular, Facultad de Ciencias, Universidad de Extremadura, 06006, Badajoz.
Mateos-Quiros, C.M.1, Garrido-Jimenez, S.1, Álvarez-Hernán, G.2, Diaz-Chamorro, S.1, Barrera-Lopez, J.F.1, Morcillo, F.J.2, Roman, A.C.1, Centeno, F.1 and Carvajal-Gonzalez, J.M. 1
1-Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06071-Badajoz, Spain. 2-Área de Biología Celular, Facultad de Ciencias, Universidad de Extremadura, 06006, Badajoz.
*Loss of epithelial Jagged 1 disrupts the integrity of adult homeostatic mammary gland (ID_34)
Sáez de Cámara A.1, Malaxetxebarria S.2, Meisel CT.3, Mitsiadis TA.3, Unda F.1, Jiménez-Rojo L.1
1 University of the Basque Country. Leioa, Bizkaia; 2 Cruces University Hospital. Barakaldo, Bizkaia; 3 University of Zurich. Zurich, Switzerland
Sáez de Cámara A.1, Malaxetxebarria S.2, Meisel CT.3, Mitsiadis TA.3, Unda F.1, Jiménez-Rojo L.1
1 University of the Basque Country. Leioa, Bizkaia; 2 Cruces University Hospital. Barakaldo, Bizkaia; 3 University of Zurich. Zurich, Switzerland
Lysosomal degradation of autophagosomes regulates the postnatal intestinal epithelium maturation (ID_79)
Gonzalo Herranz, Tamara González, Covadonga Díaz-Díaz, Marta Iborra, Nuria Martínez-Martín and Fernando Martín-Belmonte
Centro de Biología Molecular Severo Ochoa (CBMSO) CSIC-UAM, Madrid
Gonzalo Herranz, Tamara González, Covadonga Díaz-Díaz, Marta Iborra, Nuria Martínez-Martín and Fernando Martín-Belmonte
Centro de Biología Molecular Severo Ochoa (CBMSO) CSIC-UAM, Madrid
Mitochondria SOD2 regulates cell differentiation and self-renewal in male fertility (ID_50)
García-Soler B. a,b, Cepas V. c, Artime-Naveda F.a, Fernández-Vega S. a,b, Sáinz RM a,b, Mayo JC. a,b*
a_Department of Morphology and Cell Biology, Redox Biology Unit. University of Oviedo, School of Medicine, Julián Clavería 6, 33006 Oviedo, Asturias; b_University Institute of Oncology of Asturias (IUOPA). University of Oviedo. Oviedo, Asturias; c_Candiolo Cancer Institute IRCCS, Turin, Italia
García-Soler B. a,b, Cepas V. c, Artime-Naveda F.a, Fernández-Vega S. a,b, Sáinz RM a,b, Mayo JC. a,b*
a_Department of Morphology and Cell Biology, Redox Biology Unit. University of Oviedo, School of Medicine, Julián Clavería 6, 33006 Oviedo, Asturias; b_University Institute of Oncology of Asturias (IUOPA). University of Oviedo. Oviedo, Asturias; c_Candiolo Cancer Institute IRCCS, Turin, Italia
*Morphometric analysis of the skin wound healing process on gilthead seabream (Sparus aurata) fed silk nanoparticles (ID_7)
Albaladejo-Riad, N.1, Espinosa, C.1, Carissimi2, G.2, Díaz Baños F.G.2, Víllora, G. 2, & Esteban, M.A.1
1Immunobiology for aquaculture group. Department of Cell Biology and Histology. Faculty of Biology, University of Murcia, 30100 Murcia; 2Department of Physical Chemistry, Faculty of Chemistry, University of Murcia, Murcia,
Albaladejo-Riad, N.1, Espinosa, C.1, Carissimi2, G.2, Díaz Baños F.G.2, Víllora, G. 2, & Esteban, M.A.1
1Immunobiology for aquaculture group. Department of Cell Biology and Histology. Faculty of Biology, University of Murcia, 30100 Murcia; 2Department of Physical Chemistry, Faculty of Chemistry, University of Murcia, Murcia,
p53 regulation by MDM2 contributes to self-renewal and differentiation of basal stem cells in mouse and human airway epitheliumd (ID_43)
Garrido-Jimenez, S.1, Barrera-Lopez, J.F.1, Diaz-Chamorro, S 1, Mateos-Quiros, C.M.1, Rodriguez-Blanco, I.2, Marquez-Perez, F. 2, Lorenzo, M.J. 1, Centeno, F. 1, Roman, A.C. 1, Carvajal-Gonzalez, J.M. 1
1- Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06071-Badajoz, Spain. 2- Departamento de Neumología, Hospital Universitario de Badajoz, 06005 Badajoz, Spain.
Garrido-Jimenez, S.1, Barrera-Lopez, J.F.1, Diaz-Chamorro, S 1, Mateos-Quiros, C.M.1, Rodriguez-Blanco, I.2, Marquez-Perez, F. 2, Lorenzo, M.J. 1, Centeno, F. 1, Roman, A.C. 1, Carvajal-Gonzalez, J.M. 1
1- Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06071-Badajoz, Spain. 2- Departamento de Neumología, Hospital Universitario de Badajoz, 06005 Badajoz, Spain.
Rho GTPases signaling in Neuroblastoma tumors (ID_9)
Gómez-Muñoz M.A (1), Amador-Álvarez A. (2), Pardal R. (1), Vega F.M. (2)
1. Instituto de Biomedicina de Sevilla (IBiS) y Departamento de Fisiología Médica y Biofísica, Sevilla, Spain.; 2. Instituto de Biomedicina de Sevilla (IBiS) y Departamento de Biología Celular, Universidad de Sevilla, Sevilla, Spain.
Gómez-Muñoz M.A (1), Amador-Álvarez A. (2), Pardal R. (1), Vega F.M. (2)
1. Instituto de Biomedicina de Sevilla (IBiS) y Departamento de Fisiología Médica y Biofísica, Sevilla, Spain.; 2. Instituto de Biomedicina de Sevilla (IBiS) y Departamento de Biología Celular, Universidad de Sevilla, Sevilla, Spain.
Simultaneous mapping of calcium and contraction in the developing heart of zebrafish larvae (ID_89)
Salgado-Almario J.1, Vicente M.1, Molina Y.1, Martinez Sielva A.1, Vincent P.2, Domingo B.1 and Llopis J.1
1Centro Regional de Investigaciones Biomédicas (CRIB), Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain; 2Sorbonne Université, CNRS, Paris, France
Salgado-Almario J.1, Vicente M.1, Molina Y.1, Martinez Sielva A.1, Vincent P.2, Domingo B.1 and Llopis J.1
1Centro Regional de Investigaciones Biomédicas (CRIB), Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain; 2Sorbonne Université, CNRS, Paris, France
*The osteogenic differentiation of C3H10T1/2 mesenchymal cells is modulated by DLK proteins (ID_96)
Rodríguez-Cano MM1, González-Gómez MJ2, Resuela-González JL1, Baladrón V3, Nueda ML1, Laborda J1.
Laboratory of Biochemistry and Molecular Biology, Department of Inorganic and Organic Chemistry and Biochemistry, Pharmacy School 1/ Higher Technical School of Agricultural and Forestry Engineering 2/ Medical School 3/ Regional Biomedical Research Center (CRIB)/ Biomedicine Unit, UCLM/CSIC. Albacete, Spain.
Rodríguez-Cano MM1, González-Gómez MJ2, Resuela-González JL1, Baladrón V3, Nueda ML1, Laborda J1.
Laboratory of Biochemistry and Molecular Biology, Department of Inorganic and Organic Chemistry and Biochemistry, Pharmacy School 1/ Higher Technical School of Agricultural and Forestry Engineering 2/ Medical School 3/ Regional Biomedical Research Center (CRIB)/ Biomedicine Unit, UCLM/CSIC. Albacete, Spain.
*The role of NOTCH receptors in the osteoblastic differentiation of mesenchymal C3H10T1/2 cell line (ID_97)
Resuela-González, J. L.1, Rodríguez-Cano, M. 1, González-Gómez, M. J. 2, Baladrón, V 3, Nueda, M. L. 1.
Laboratory of Biochemistry and Molecular Biology, Department of Inorganic and Organic Chemistry and Biochemistry, Pharmacy School 1/ Higher Technical School of Agricultural and Forestry Engineering 2/ Medical School 3/ Regional Biomedical Research Center (CRIB)/ Biomedicine Unit, UCLM/CSIC. Albacete, Spain.
Resuela-González, J. L.1, Rodríguez-Cano, M. 1, González-Gómez, M. J. 2, Baladrón, V 3, Nueda, M. L. 1.
Laboratory of Biochemistry and Molecular Biology, Department of Inorganic and Organic Chemistry and Biochemistry, Pharmacy School 1/ Higher Technical School of Agricultural and Forestry Engineering 2/ Medical School 3/ Regional Biomedical Research Center (CRIB)/ Biomedicine Unit, UCLM/CSIC. Albacete, Spain.
Symposium 3: “Transcription/Translation”
Chairs:
Javier León. IBBTEC. Cantabria. Spain
Javier Martínez-Useros. University Hospital "Fundacion Jimenez Diaz". Spain
Javier León. IBBTEC. Cantabria. Spain
Javier Martínez-Useros. University Hospital "Fundacion Jimenez Diaz". Spain
*Activity of CDK9 PROTAC (THAL-SNS-032) in HER2 positive breast cancer (ID_ 19)
Noblejas-López MDM1, Gandullo-Sánchez L2, Galán-Moya EM1,3, López-Rosa R1, Tébar-García D1, Nieto-Jiménez C1, Burgos M1, Pandiella 2, and Ocana A1,4
1 Translational Oncology Laboratory, Centro Regional de Investigaciones Biomédicas, Castilla‐La Mancha University (CRIB‐UCLM), Albacete, Castilla-La Mancha, Spain; 2 Instituto de Biología Molecular y Celular del Cáncer and CIBERONC. CSIC Salamanca, Castilla y León, Spain; 3 Faculty of Nursing, Castilla-La Mancha University (UCLM), Albacete, Spain; 4 Hospital Clínico Universitario San Carlos, IDISSC and CIBERONC, Madrid, Spain.
1 Translational Oncology Laboratory, Centro Regional de Investigaciones Biomédicas, Castilla‐La Mancha University (CRIB‐UCLM), Albacete, Castilla-La Mancha, Spain; 2 Instituto de Biología Molecular y Celular del Cáncer and CIBERONC. CSIC Salamanca, Castilla y León, Spain; 3 Faculty of Nursing, Castilla-La Mancha University (UCLM), Albacete, Spain; 4 Hospital Clínico Universitario San Carlos, IDISSC and CIBERONC, Madrid, Spain.
Pirin as a modulator of JARID1B gene expression and prognostic marker of human melanoma (ID_54)
Penas Lago C 1, Rasero J 2,3, Ezkurra PA 1, Izu R2, Andollo N1, Bosserhof AK 4,5, Alonso S 6, Asumendi A 1,2 and Boyano MD 1,2.
(1) Department of Cell Biology and Histology. Faculty of Medicine and Nursing, University of the Basque Country-UPV/EHU, Leioa, Bizkaia; (2) Biocruces Bizkaia Health Research Institute, Barakaldo, Bizkaia; (3) Department of Psychology, Dietrich College of Humanities and Social Sciences. Carnegie Mellon University, Pittsburg, Pensilvania; (4) Institute of Biochemistry, Friedrich-Alexander-Universität, Erlangen; (5) Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen; (6) Department of Genetics, Physical Anthropology and Animal Physiology. Faculty of Science and Technology, University of the Basque Country-UPV/EHU, Leioa, Bizkaia.
Penas Lago C 1, Rasero J 2,3, Ezkurra PA 1, Izu R2, Andollo N1, Bosserhof AK 4,5, Alonso S 6, Asumendi A 1,2 and Boyano MD 1,2.
(1) Department of Cell Biology and Histology. Faculty of Medicine and Nursing, University of the Basque Country-UPV/EHU, Leioa, Bizkaia; (2) Biocruces Bizkaia Health Research Institute, Barakaldo, Bizkaia; (3) Department of Psychology, Dietrich College of Humanities and Social Sciences. Carnegie Mellon University, Pittsburg, Pensilvania; (4) Institute of Biochemistry, Friedrich-Alexander-Universität, Erlangen; (5) Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen; (6) Department of Genetics, Physical Anthropology and Animal Physiology. Faculty of Science and Technology, University of the Basque Country-UPV/EHU, Leioa, Bizkaia.
Symposium 4: “Chromatin dynamics and epigenetics in development”
Chairs:
Paz Herráez. Universidad de León. León. Spain
Crisanto Gutiérrez. Centro de Biología Molecular Severo Ochoa (CBMSO). Madrid. Spain
Paz Herráez. Universidad de León. León. Spain
Crisanto Gutiérrez. Centro de Biología Molecular Severo Ochoa (CBMSO). Madrid. Spain
In vitro and in vivo rescue of resistance to BET inhibitors by targeting PLK1 in triple negative breast cancer (ID_75)
Nieto-Jiménez, C1; Galán-Moya, EM2; Corrales-Sánchez, V3; Noblejas-López, MdM2,4; Burgos, M2; Montero, JC 5; Gómez-Juárez, M 4; Granada-Picazo, M 4; Pandiella, A 5; Ocaña, A 1,2,4.
1 Hospital Clínico Universitario San Carlos, IDISSC and CIBERONC, Madrid, Spain. 2 Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, Albacete, Spain; 3 Hospital Virgen de la Luz, Cuenca, Spain, 4 Translational Research Unit, Albacete University Hospital, Albacete, Spain; 5 Instituto de Biología Molecular y Celular del Cáncer del CSIC, IBSAL and CIBERONC, Salamanca, Spain
Nieto-Jiménez, C1; Galán-Moya, EM2; Corrales-Sánchez, V3; Noblejas-López, MdM2,4; Burgos, M2; Montero, JC 5; Gómez-Juárez, M 4; Granada-Picazo, M 4; Pandiella, A 5; Ocaña, A 1,2,4.
1 Hospital Clínico Universitario San Carlos, IDISSC and CIBERONC, Madrid, Spain. 2 Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, Albacete, Spain; 3 Hospital Virgen de la Luz, Cuenca, Spain, 4 Translational Research Unit, Albacete University Hospital, Albacete, Spain; 5 Instituto de Biología Molecular y Celular del Cáncer del CSIC, IBSAL and CIBERONC, Salamanca, Spain
Sensing nuclear compaction gradients: a new model to describe compaction phase transitions in cell nuclei (ID_62)
Zamora-Carreras, H.1,4, López-Menéndez, H.2,3, Casselli, N.2, 3, Redondo-Muñoz, J.4, 5, Monroy, F.2, 3, and Roda-Navarro, P.1, 3
1 Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain, 2 Faculty of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain; 3 Hospital Doce de Octubre Health Research Institute (imas12), Madrid, Spain; 4 Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain; 5 Lydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom
Zamora-Carreras, H.1,4, López-Menéndez, H.2,3, Casselli, N.2, 3, Redondo-Muñoz, J.4, 5, Monroy, F.2, 3, and Roda-Navarro, P.1, 3
1 Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain, 2 Faculty of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain; 3 Hospital Doce de Octubre Health Research Institute (imas12), Madrid, Spain; 4 Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain; 5 Lydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom
The SUMO and ubiquitin pathways control DNA replication (ID_67)
Martín-Rufo R., Pardo A., Álvarez-Montero A., Gómez-Vicentefranqueira M., Lecona E.
Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid
Martín-Rufo R., Pardo A., Álvarez-Montero A., Gómez-Vicentefranqueira M., Lecona E.
Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid
Symposium 5: “Metabolism and Signal Transduction”
Chairs:
Custodia García. Universidad Rey Juan Carlos. Madrid. Spain
Mar Malagón. Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Spain
Custodia García. Universidad Rey Juan Carlos. Madrid. Spain
Mar Malagón. Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Spain
*A hypomethylating treatment inhibits autophagy in pancreatic cancer cells and induces effective apoptosis (ID_20)
Montenegro MF1, Martí-Díaz R1, Navarro-Incio AM2, Tolivia-Fernández J2, Cabezas-Herrera J3, Sánchez-del-Campo L1, Rodríguez-López JN1
1Department of Biochemistry and Molecular Biology A, School of Biology, IMIB-University of Murcia, 30100, Murcia, Spain. 2Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Spain. 3Translational Cancer Research Group, University Hospital Virgen de la Arrixaca, IMIB, Murcia, Spain.
Montenegro MF1, Martí-Díaz R1, Navarro-Incio AM2, Tolivia-Fernández J2, Cabezas-Herrera J3, Sánchez-del-Campo L1, Rodríguez-López JN1
1Department of Biochemistry and Molecular Biology A, School of Biology, IMIB-University of Murcia, 30100, Murcia, Spain. 2Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Spain. 3Translational Cancer Research Group, University Hospital Virgen de la Arrixaca, IMIB, Murcia, Spain.
CITK and ZIPK differentially control NMII activation, lamellipodial dynamics and cell polarity and division in migrating cells (ID_106)
Marina Garrido-Casado, Clémence Thiant and Miguel Vicente-Manzanares
Molecular Mechanisms Program, Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, 37007 Salamanca, Spain.
Marina Garrido-Casado, Clémence Thiant and Miguel Vicente-Manzanares
Molecular Mechanisms Program, Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, 37007 Salamanca, Spain.
Crosstalk between survival pathways in glioblastoma chemoresistance (ID_ 76)
Zarzuela, L., Durán, R. V., Tomé, M.
Centro Andaluz de Biología Molecular y Medicina Regenerativa, CABIMER – CSIC, Sevilla, Sevilla.
Zarzuela, L., Durán, R. V., Tomé, M.
Centro Andaluz de Biología Molecular y Medicina Regenerativa, CABIMER – CSIC, Sevilla, Sevilla.
Functional characterization of Sur8 and its implication in renal pathophysiology (ID_ 105)
M.I. GarcíaGonzálezI, V.M. CorderoI, M.P. de LucasII, B. AntaII, J.L. OlivaIII, A. BanzoI, P. PalauI, D. SardónVI, M.R. BaqueroI, J.M. RojasII, D. PeñaJiménez I, M. Yunta I
IUnidad de Investigación Biomédica, Universidad Alfonso X El Sabio, Villanueva de la Cañada, Madrid. IIUnidad de Biología Celular, Unidad Funcional de Investigación en Enfermedades Crónicas, Majadahonda, Madrid. III Unidad de Senescencia Celular, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto Carlos III, Majadahonda, Madrid. IV Unidad de Anatomía Patológica, Hospital Clínico Veterinario, Universidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid.
M.I. GarcíaGonzálezI, V.M. CorderoI, M.P. de LucasII, B. AntaII, J.L. OlivaIII, A. BanzoI, P. PalauI, D. SardónVI, M.R. BaqueroI, J.M. RojasII, D. PeñaJiménez I, M. Yunta I
IUnidad de Investigación Biomédica, Universidad Alfonso X El Sabio, Villanueva de la Cañada, Madrid. IIUnidad de Biología Celular, Unidad Funcional de Investigación en Enfermedades Crónicas, Majadahonda, Madrid. III Unidad de Senescencia Celular, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto Carlos III, Majadahonda, Madrid. IV Unidad de Anatomía Patológica, Hospital Clínico Veterinario, Universidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid.
Glut1 as colorectal cancer biomarker in liquid biopsy (ID_102)
JL Román1, José Manuel García-Martínez1, Rosa Martín-Orozco1, Ana Chocarro-Calvo1, María Gutiérrez-Salmerón1, Alberto Sanchez1, Ana Ramírez1, María Carmen Fiuza3, Antonio De la Vieja2, Custodia García-Jiménez1.
1Universidad Rey Juan Carlos, Alcorcón, ES, 2Instituto de Salud Carlos III, Majadahonda, ES, 3Departamento de cirugía, Hospital Universitario Fundación Alcorcón, Alcorcón, ES
Identification of Lipid Biomarkers of Malignant Progression of Cutaneous Melanoma by MALDI-IMS (ID_ 108)
Huergo Baños C1, Garate J1, Fernández R1, Martín J2, Zabalza I3, Artola JL4, Martí RM5, Velasco V6, Astigarraga E7, Barreda-Gómez G7, Boyano MD6,8 and Fernández J.A1
1Department of Physical Chemistry, Faculty of Science and Technology, UPV/EHU. Leioa, Spain.2Department of Electricity and Electronics, Faculty of Science and Technology, UPV/EHU. Leioa, Spain.3 Department of Pathology. Galdakao-Usansolo Hospital. Galdakao, Spain.4 Department of Dermatology. Galdakao-Usansolo Hospital. Galdakao, Spain.5 Department of Dermatology. Hospital Universitari Arnau de Vilanova. Lleida, Spain.6 Biocruces Bizkaia Institute, Cruces University Hospital. Barakaldo, Spain 7 Department I+D, IMG Pharma Biotech S.L. BIC Bizkaia. Derio, Spain. 8 Department of Cell Biology and Histology, Faculty of Medicine and Nursing, UPV/EHU. Leioa, Spain
Huergo Baños C1, Garate J1, Fernández R1, Martín J2, Zabalza I3, Artola JL4, Martí RM5, Velasco V6, Astigarraga E7, Barreda-Gómez G7, Boyano MD6,8 and Fernández J.A1
1Department of Physical Chemistry, Faculty of Science and Technology, UPV/EHU. Leioa, Spain.2Department of Electricity and Electronics, Faculty of Science and Technology, UPV/EHU. Leioa, Spain.3 Department of Pathology. Galdakao-Usansolo Hospital. Galdakao, Spain.4 Department of Dermatology. Galdakao-Usansolo Hospital. Galdakao, Spain.5 Department of Dermatology. Hospital Universitari Arnau de Vilanova. Lleida, Spain.6 Biocruces Bizkaia Institute, Cruces University Hospital. Barakaldo, Spain 7 Department I+D, IMG Pharma Biotech S.L. BIC Bizkaia. Derio, Spain. 8 Department of Cell Biology and Histology, Faculty of Medicine and Nursing, UPV/EHU. Leioa, Spain
Identification of new functions of Pgc1 and mitochondrial biogenesis in epicardium development (ID_65) Portella-Fortuny R1,2, Ramiro-Pareta M1,2, Müller-Sánchez C1, Gerpe A3, Pardo R3, Reina M1, Soriano F.X1,4, Villena J.A3 and Martínez-Estrada O.M1,2
1Celltec-UB, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona; 2Institute of Biomedicine (IBUB), University of Barcelona, Barcelona; 3Laboratory of Metabolism and Obesity, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona; 4Institut de Neurociències, Universitat de Barcelona, Barcelona
1Celltec-UB, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona; 2Institute of Biomedicine (IBUB), University of Barcelona, Barcelona; 3Laboratory of Metabolism and Obesity, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona; 4Institut de Neurociències, Universitat de Barcelona, Barcelona
Induction of oxidative stress and different metabolic profiles with polymeric-coated IONPs (ID_ 68)
Daviu N., Portilla Y., Barber DF.
Centro Nacional de Biotecnología (CNB-CSIC), Madrid.
Daviu N., Portilla Y., Barber DF.
Centro Nacional de Biotecnología (CNB-CSIC), Madrid.
Metformin induces cell death of prostate cancer cells by reticulum stress and re-location of GLUT1 protein. (ID_86)
Alba Moran-Alvarez1,2, Pedro González-Menéndez3, Rafael Cernuda-Cernuda1, Juan C. Mayo1,2 and Rosa M. Sainz1,2
1Departamento de Morfología y Biología Celular. 2Instituto Universitario de Oncología del Principado de Asturias (IUOPA). Universidad de Oviedo. 3Institut de Genetique Moleculaire de Montpellier, University of Montpellier, CNRS
Alba Moran-Alvarez1,2, Pedro González-Menéndez3, Rafael Cernuda-Cernuda1, Juan C. Mayo1,2 and Rosa M. Sainz1,2
1Departamento de Morfología y Biología Celular. 2Instituto Universitario de Oncología del Principado de Asturias (IUOPA). Universidad de Oviedo. 3Institut de Genetique Moleculaire de Montpellier, University of Montpellier, CNRS
*miRNA-based therapy to overcome chemoresistance in cervix cancer (ID_ 98)
Muñoz-Galdeano, T.1, Reigada, D1, Gamarra García-Bermejo, M2, Soto Neira, A1, De la Barreda, A1, Nieto-Díaz, M1, M Maza, R1.
(1)Grupo de Neuroprotección Molecular. Hospital Nacional de Parapléjicos. Unidad e Investigación. Finca La Peraleda s/n; 45004, Toledo, Toledo. (2) Laboratory of Local Translation in Neurons and Glia. Achucarro Basque Center for Neuroscience. Science Park of the UPV/EHU; B. Sarriena, s/n.. Leioa, Bilbao.
Muñoz-Galdeano, T.1, Reigada, D1, Gamarra García-Bermejo, M2, Soto Neira, A1, De la Barreda, A1, Nieto-Díaz, M1, M Maza, R1.
(1)Grupo de Neuroprotección Molecular. Hospital Nacional de Parapléjicos. Unidad e Investigación. Finca La Peraleda s/n; 45004, Toledo, Toledo. (2) Laboratory of Local Translation in Neurons and Glia. Achucarro Basque Center for Neuroscience. Science Park of the UPV/EHU; B. Sarriena, s/n.. Leioa, Bilbao.
New mechanisms promoting metastasis and survival upon metabolic stress (ID_14)
Vivas-Garcia Y1, Louphrasitthiphol P1, Sánchez del Campo L2, Goding C1.
1Department of Biochemistry and Molecular Biology A, School of Biology, IMIB-University of Murcia, 30100, Murcia, Spain. 2Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Spain. 3Translational Cancer Research Group, University Hospital Virgen de la Arrixaca, IMIB, Murcia, Spain.
Vivas-Garcia Y1, Louphrasitthiphol P1, Sánchez del Campo L2, Goding C1.
1Department of Biochemistry and Molecular Biology A, School of Biology, IMIB-University of Murcia, 30100, Murcia, Spain. 2Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Spain. 3Translational Cancer Research Group, University Hospital Virgen de la Arrixaca, IMIB, Murcia, Spain.
*New three-dimensional in vitro model to study tumour - stroma interactions in melanoma progression. (ID_ 110)
Sánchez-De la Cruz A.1, Ramírez-Sánchez A.1, Gutiérrez-Salmerón M. 1, García-Martínez JM. 1, De la Vieja, A.2, García-Jiménez C.1, Chocarro-Calvo, A.1.
1 Universidad Rey Juan Carlos, Alcorcón, Madrid. 2 UFIEC, Instituto de Salud Carlos III, Majadahonda, Madrid
Sánchez-De la Cruz A.1, Ramírez-Sánchez A.1, Gutiérrez-Salmerón M. 1, García-Martínez JM. 1, De la Vieja, A.2, García-Jiménez C.1, Chocarro-Calvo, A.1.
1 Universidad Rey Juan Carlos, Alcorcón, Madrid. 2 UFIEC, Instituto de Salud Carlos III, Majadahonda, Madrid
Optimization of the sperm DNA oxidation analysis by the 8-hydroxy-2'-deoxyguanosine (8-OHdG) in Sus scrofa (domestic pig) (ID_94)
Lacalle E., Fernández-González C., Rivas G., Martínez-Pastor F., Soriano-Úbeda C.
Institute of Animal Health and Cattle Development (INDEGSAL) and Department of Molecular Biology (Cell Biology), University of León, León 24071, Spain.
Lacalle E., Fernández-González C., Rivas G., Martínez-Pastor F., Soriano-Úbeda C.
Institute of Animal Health and Cattle Development (INDEGSAL) and Department of Molecular Biology (Cell Biology), University of León, León 24071, Spain.
Photodynamic therapy optimization after 5-Fluorouracil treatment in Squamous Cell Carcinoma (ID_ 29)
Nicolás Morala J1,2, Terrén Gómez S1, Juarranz De la Fuente A1,2 , González Rodríguez S2,3.
1.Universidad Autónoma de Madrid; 2. Instituto Ramón y Cajal de Investigación Sanitaria;3. Universidad de Alcalá de Henares
Nicolás Morala J1,2, Terrén Gómez S1, Juarranz De la Fuente A1,2 , González Rodríguez S2,3.
1.Universidad Autónoma de Madrid; 2. Instituto Ramón y Cajal de Investigación Sanitaria;3. Universidad de Alcalá de Henares
Role of the NADPH oxidase NOX4 in the response to TGF-beta in hepatocelular carcinoma cells (ID_ 63)
Espinosa-Sotelo R.1,2,*, Almodóvar-Balletbò X.1, Fusté N.P.1,2, Pons G.3, Bertran E.1,2, Fabregat I1,2,3.
1 TGF-β and Cancer Group. Oncobell Program. Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; 2 Oncology Program, CIBEREHD, National Biomedical Research Institute on Liver and Gastrointestinal Diseases, Instituto de Salud Carlos III, Spain; 3 Department of Physiological Sciences. Faculty of Medicine and Health Sciences. University of Barcelona, Spain
Espinosa-Sotelo R.1,2,*, Almodóvar-Balletbò X.1, Fusté N.P.1,2, Pons G.3, Bertran E.1,2, Fabregat I1,2,3.
1 TGF-β and Cancer Group. Oncobell Program. Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; 2 Oncology Program, CIBEREHD, National Biomedical Research Institute on Liver and Gastrointestinal Diseases, Instituto de Salud Carlos III, Spain; 3 Department of Physiological Sciences. Faculty of Medicine and Health Sciences. University of Barcelona, Spain
Skin squamous cell carcinoma cells resistant to photodynamic therapy have a glycolytic phenotype and metformin treatment reverses it (ID_39)
Mascaraque-Checa M1, Santiago JL2, González S3, Gilaberte Y4, Juarranz Á1.
1) Universidad Autónoma de Madrid, Dept. Biology, Madrid, Spain and Instituto Ramón y Cajal de Investigaciones Sanitarias, IRYCIS, 28034 Madrid, Spain; 2) Hospital General Universitario de Ciudad Real, Dept. Dermatology, Ciudad Real, Spain; 4) Universidad de Alcalá, Dept. Medicine and Medical Specialities, Madrid, Spain; 5) Hospital Universitario Miguel Servet, Dept. Dermatology, Zaragoza, Spain.
Mascaraque-Checa M1, Santiago JL2, González S3, Gilaberte Y4, Juarranz Á1.
1) Universidad Autónoma de Madrid, Dept. Biology, Madrid, Spain and Instituto Ramón y Cajal de Investigaciones Sanitarias, IRYCIS, 28034 Madrid, Spain; 2) Hospital General Universitario de Ciudad Real, Dept. Dermatology, Ciudad Real, Spain; 4) Universidad de Alcalá, Dept. Medicine and Medical Specialities, Madrid, Spain; 5) Hospital Universitario Miguel Servet, Dept. Dermatology, Zaragoza, Spain.
Sting triggers NF-κB-dependent proinflammatory effects in renal tubular cells and kidney injured tissu (ID_26)
García Giménez J, Córdoba David G, Ortiz A, Ramos AM.
Nephrology and Hypertension Laboratory; Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid, Spain.
García Giménez J, Córdoba David G, Ortiz A, Ramos AM.
Nephrology and Hypertension Laboratory; Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid, Spain.
*Tenofovir modulates Semaphorin 4D signaling and regulates bone homeostasis, which can be counteracted by dipyridamole and adenosine A2A receptor (ID_ 13)
Llamas-Granda P, Martin-Rodríguez L, Largo R, Herrero-Beaumont G, Mediero A.
Bone and Joint Research Unit. IIS-Fundación Jiménez Díaz UAM. Madrid 28040, Spain
Llamas-Granda P, Martin-Rodríguez L, Largo R, Herrero-Beaumont G, Mediero A.
Bone and Joint Research Unit. IIS-Fundación Jiménez Díaz UAM. Madrid 28040, Spain
*Tenofovir regulates myogenesis by inhibition of AMPK and modulation of purinergic receptors and dipyridamole reverts the effect (ID_12)
Marco-Bonilla M, Herencia R, Largo R., Herrero-Beaumont G, Mediero A.
Bone and Joint Research Unit. IIS-Fundación Jiménez Díaz UAM. Madrid 28040, Spain
Marco-Bonilla M, Herencia R, Largo R., Herrero-Beaumont G, Mediero A.
Bone and Joint Research Unit. IIS-Fundación Jiménez Díaz UAM. Madrid 28040, Spain
The NADPH Oxidase NOX4 Inhibits c-Myc and Nrf2 Activation and Protects Cells from Oxidative Stress in Hepatocellular Carcinoma (ID_73)
1,2Peñuelas-Haro,I.,1Crosas-Molist, E., 3Zhang, S., 3Knaus, U.G., 1,2Bertran, E., 1,2,4Fabregat, I.
1TGF- β and Cancer Group. Oncobell Program. IDIBELL, Barcelona, Spain; 2Oncology Program, CIBEREHD, Instituto de Salud Carlos III, Barcelona, Spain; 3Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland. 4Dept. de Ciències Fisiològiques II, Universitat de Barcelona, Barcelona, Spain.
1,2Peñuelas-Haro,I.,1Crosas-Molist, E., 3Zhang, S., 3Knaus, U.G., 1,2Bertran, E., 1,2,4Fabregat, I.
1TGF- β and Cancer Group. Oncobell Program. IDIBELL, Barcelona, Spain; 2Oncology Program, CIBEREHD, Instituto de Salud Carlos III, Barcelona, Spain; 3Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland. 4Dept. de Ciències Fisiològiques II, Universitat de Barcelona, Barcelona, Spain.
Vitamin D-mediated inhibition of NF-kB activity reduces activation of the NOX/ROS/AMPK/EP300 axis in colorectal cancer. New antitumor mechanism of vitamin D. (ID_109)
Navarro-Ramírez E1, Román J.L1, Gutiérrez-Salmerón M1, Ramírez-Sánchez A1, Sánchez-De la Cruz A1, Martín-Orozco RM1, Chocarro-Calvo, A1, Larriba MJ2, Muñoz A2, García-Martínez JM1 García-Jiménez C1
1Universidad Rey Juan Carlos, Alcorcón, Madrid. 2Departamento de Biología del cáncer, Instituto de Investigaciones Biomédicas"Alberto Sols" CSIC-UAM, Madrid
Navarro-Ramírez E1, Román J.L1, Gutiérrez-Salmerón M1, Ramírez-Sánchez A1, Sánchez-De la Cruz A1, Martín-Orozco RM1, Chocarro-Calvo, A1, Larriba MJ2, Muñoz A2, García-Martínez JM1 García-Jiménez C1
1Universidad Rey Juan Carlos, Alcorcón, Madrid. 2Departamento de Biología del cáncer, Instituto de Investigaciones Biomédicas"Alberto Sols" CSIC-UAM, Madrid
*What is the pathogenic meaning of chondrocyte hypertrophy in osteoarthritis? Effect of Evc deletion through Hedgehog signaling (ID_ 21)
Lamuedra A1, Gratal P1, Ruiz-Perez VL2,3, Palencia-Campos A2, Portal-Núñez S1,4, Herrero-Beaumont G1, Largo R1
1Instituto de Investigación Sanitaria-Fundación Jiménez Díaz-UAM, Madrid, Madrid; 2Instituto de Investigaciones Biomédicas 'Alberto Sols', CSIC-UAM, Madrid, Madrid; 3Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-UAM, Madrid, Madrid; 4Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, Alcorcón, Madrid
Lamuedra A1, Gratal P1, Ruiz-Perez VL2,3, Palencia-Campos A2, Portal-Núñez S1,4, Herrero-Beaumont G1, Largo R1
1Instituto de Investigación Sanitaria-Fundación Jiménez Díaz-UAM, Madrid, Madrid; 2Instituto de Investigaciones Biomédicas 'Alberto Sols', CSIC-UAM, Madrid, Madrid; 3Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-UAM, Madrid, Madrid; 4Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, Alcorcón, Madrid
Wnt5a-JNK planar cell polarity-related signaling pathway regulates IL6 expression in mouse preadipocytes (ID_ 46)
Díaz-Chamorro, S.1, Garrido-Jiménez, S.1, Barrera-López, J.F.1, Mateos-Quirós, C. M.1, Lorenzo, M.J.2, Román, A.C.1, Bernardo, E.3, Sabio, G.3, Centeno, F.1, and Carvajal-González, J.M.1
1Department of Biochemistry, Molecular Biology and Genetics, Faculty of Sciences, University of Extremadura, Badajoz, Spain; 2Department of Biochemistry, Molecular Biology and Genetics, Faculty of Veterinary Sciences, University of Extremadura, Cáceres, Spain; 3Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Díaz-Chamorro, S.1, Garrido-Jiménez, S.1, Barrera-López, J.F.1, Mateos-Quirós, C. M.1, Lorenzo, M.J.2, Román, A.C.1, Bernardo, E.3, Sabio, G.3, Centeno, F.1, and Carvajal-González, J.M.1
1Department of Biochemistry, Molecular Biology and Genetics, Faculty of Sciences, University of Extremadura, Badajoz, Spain; 2Department of Biochemistry, Molecular Biology and Genetics, Faculty of Veterinary Sciences, University of Extremadura, Cáceres, Spain; 3Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Symposium 6: “Metabolic homeostasis and disease”
Chairs:
Juan Llopis. Universidad de Castilla La Mancha (UCLM). Spain
Miguel R. Campanero. CBMSO. Madrid. Spain
Juan Llopis. Universidad de Castilla La Mancha (UCLM). Spain
Miguel R. Campanero. CBMSO. Madrid. Spain
*A comparative evaluation of bioaccumulation and induction of oxidative stress by waterborne copper (Cu) and arsenic (As), as dissolved salts (DS) and nanoparticles (NP), in larvae of European seabass (Dicentrarchus labrax, L.) (ID_ 77)
Canalejo Raya, A.a; Granado-Castro, M.D.b; Díaz de Alba, M.b; Espada-Bellido, E.b; Casanueva Marenco, M.J.b; Galindo Riaño, M.D.b; Torronteras, R.a
a Department of Integrated Sciences/ Research Center RENSMA, University of Huelva. Huelva. B Department of Analytical Chemistry. Faculty of Science. University of Cádiz. Cádiz.
Canalejo Raya, A.a; Granado-Castro, M.D.b; Díaz de Alba, M.b; Espada-Bellido, E.b; Casanueva Marenco, M.J.b; Galindo Riaño, M.D.b; Torronteras, R.a
a Department of Integrated Sciences/ Research Center RENSMA, University of Huelva. Huelva. B Department of Analytical Chemistry. Faculty of Science. University of Cádiz. Cádiz.
Browning of white adipose tissue modulates prostate cancer growth in vitro (ID_ 66)
Álvarez-Artime A.a,b, Garcia-Soler B.a,b, Cernuda-Cernuda R.a, Mayo JC.a,b,* Sainz RM.a,b*
a. Department of Morphology and Cell Biology, Redox Biology Unit. University of Oviedo, Facultad de Medicina, Julian Clavería 6, 33006 Oviedo, Asturias. b. University Institute of Oncology of Asturias (IUOPA), Santiago Gascón building, Fernando Bongera s/n, 33006 Oviedo, Asturias.
Álvarez-Artime A.a,b, Garcia-Soler B.a,b, Cernuda-Cernuda R.a, Mayo JC.a,b,* Sainz RM.a,b*
a. Department of Morphology and Cell Biology, Redox Biology Unit. University of Oviedo, Facultad de Medicina, Julian Clavería 6, 33006 Oviedo, Asturias. b. University Institute of Oncology of Asturias (IUOPA), Santiago Gascón building, Fernando Bongera s/n, 33006 Oviedo, Asturias.
*Implication of CEMIP in the malignant progression of cutaneous melanoma (ID_ 11)
Larrinaga M1, Agüera-Lorente A1, Boyano MD1,2, Cancho-Galan G2, Asumendi A1,2, Apraiz A1,2.
1Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, Vizcaya. 2Biocruces-Bizkaia Health Research Institute, Barakaldo, Vizcaya
Larrinaga M1, Agüera-Lorente A1, Boyano MD1,2, Cancho-Galan G2, Asumendi A1,2, Apraiz A1,2.
1Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, Vizcaya. 2Biocruces-Bizkaia Health Research Institute, Barakaldo, Vizcaya
Influence of peritoneal fluid from women with endometriosis on the location of the SPAM1 protein in human sperm (ID_ 18)
Sáez-Espinosa, P1,3; Velasco, I1,2,3; López-Botella, A1,3; Robles-Gómez, L1; Acién, MI2,3; Gómez-Torres, MJ1
1Departamento de Biotecnología, Universidad de Alicante, Alicante, España; 2Hospital Universitario San Juan de Alicante, Servicio de Ginecología y Obstetricia, San Juan de Alicante, España; 3FISABIO – Hospital Universitario de San Juan de Alicante, San Juan de Alicante, España
Sáez-Espinosa, P1,3; Velasco, I1,2,3; López-Botella, A1,3; Robles-Gómez, L1; Acién, MI2,3; Gómez-Torres, MJ1
1Departamento de Biotecnología, Universidad de Alicante, Alicante, España; 2Hospital Universitario San Juan de Alicante, Servicio de Ginecología y Obstetricia, San Juan de Alicante, España; 3FISABIO – Hospital Universitario de San Juan de Alicante, San Juan de Alicante, España
Internalization of magnetic nanodisks in melanoma cells for cancer treatment (ID_ 59)
R. Zurbano,1 C. Redondo, 1 J. Arlucea,2 C. Penas,2 M. D. Boyano,2,3 I. K.Schuller,4 and R. Morales.5,6
1. Department of Physical-Chemistry, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. 2. Department of Cell Biology and Histology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. 3. Biocruces Health Research Institute, 48903 Barakaldo, Spain. 4. Center for Advanced Nanoscience and Department of Physics, University of California San Diego, La Jolla, California 92093, United States. 5. Department of Physical-Chemistry & BCMaterials, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. 6. IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain.
R. Zurbano,1 C. Redondo, 1 J. Arlucea,2 C. Penas,2 M. D. Boyano,2,3 I. K.Schuller,4 and R. Morales.5,6
1. Department of Physical-Chemistry, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. 2. Department of Cell Biology and Histology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. 3. Biocruces Health Research Institute, 48903 Barakaldo, Spain. 4. Center for Advanced Nanoscience and Department of Physics, University of California San Diego, La Jolla, California 92093, United States. 5. Department of Physical-Chemistry & BCMaterials, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. 6. IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain.
Microglia activation and TNF-α production in the dentate gyrus of mice chronically exposed to natural air pollution. (ID_ 85)
Navarro-Sempere, A.1; Martínez-Peinado, P1.; Rodrigues, A.S.2.3; Garcia, P.V.2.4; Camarinho, R.2.3; García, M.1*; Segovia, Y.1*
1 Department of Biotechnology, Faculty of Science, University of Alicante. Apartado 99, 03080 Alicante, Spain. 2Faculty of Sciences and Technology, University of the Azores, 9501-801, Ponta Delgada, Portugal. 3 IVAR, Research Institute for Volcanology and Risk Assessment, University of the Azores, 9501-801 Ponta Delgada, Portugal. 4 cE3c, Centre for Ecology, Evolution and Environmental Changes, and Azorean Biodiversity Group, University of the Azores, 9501-801 Ponta Delgada, Portugal
Navarro-Sempere, A.1; Martínez-Peinado, P1.; Rodrigues, A.S.2.3; Garcia, P.V.2.4; Camarinho, R.2.3; García, M.1*; Segovia, Y.1*
1 Department of Biotechnology, Faculty of Science, University of Alicante. Apartado 99, 03080 Alicante, Spain. 2Faculty of Sciences and Technology, University of the Azores, 9501-801, Ponta Delgada, Portugal. 3 IVAR, Research Institute for Volcanology and Risk Assessment, University of the Azores, 9501-801 Ponta Delgada, Portugal. 4 cE3c, Centre for Ecology, Evolution and Environmental Changes, and Azorean Biodiversity Group, University of the Azores, 9501-801 Ponta Delgada, Portugal
Morphometric analysis of the skin wound healing process on gilthead seabream (Sparus aurata) fed silk nanoparticles (ID_ 32)
Albaladejo-Riad, N. 1, Espinosa, C. 1, Carissimi2, G. 2, Díaz Baños F.G. 2, Víllora, G. 2, & Esteban, M.A. 1
1Immunobiology for aquaculture group. Department of Cell Biology and Histology. Faculty of Biology, University of Murcia, 30100 Murcia; 2Department of Physical Chemistry, Faculty of Chemistry, University of Murcia, Murcia,
Albaladejo-Riad, N. 1, Espinosa, C. 1, Carissimi2, G. 2, Díaz Baños F.G. 2, Víllora, G. 2, & Esteban, M.A. 1
1Immunobiology for aquaculture group. Department of Cell Biology and Histology. Faculty of Biology, University of Murcia, 30100 Murcia; 2Department of Physical Chemistry, Faculty of Chemistry, University of Murcia, Murcia,
p73 regulates cell junction dynamics during vascular morphogenesis through the regulation of AMOT/YAP pathwaya (ID_ 71)
Maeso-Alonso, L1,2., Alonso Olivares, H1,2., Martínez-García, N1,2., Claesson-Welsh, L3., Holmgren, L4., Fernández-Corona, A5., Marques, MM6 & Marin, MC1,2.
1Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain; 2Dept. of Molecular Biology, University of Leon, Leon, Spain, 3Dept. of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 4Dept. of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden ;5Servicio de Ginecología, Complejo Asistencial Universitario de León (CAULE), León, Spain; 6Dept. of Animal Production, University of Leon, Leon, Spain.
Maeso-Alonso, L1,2., Alonso Olivares, H1,2., Martínez-García, N1,2., Claesson-Welsh, L3., Holmgren, L4., Fernández-Corona, A5., Marques, MM6 & Marin, MC1,2.
1Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain; 2Dept. of Molecular Biology, University of Leon, Leon, Spain, 3Dept. of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 4Dept. of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden ;5Servicio de Ginecología, Complejo Asistencial Universitario de León (CAULE), León, Spain; 6Dept. of Animal Production, University of Leon, Leon, Spain.
Pan-Bcl2 inhibitor obatoclax synergizes with cisplatin to boost apoptosis and overcome resistance in triple negative breast cancer (ID_ 100)
López-Rosa R1*, Tébar-García D1*, Noblejas-López MM1, Nuncia-Cantarero N1, Nieto-Jiménez C1, Burgos M1 and Galán-Moya EM1,2
1Translational Research Unit, Centro Regional de Investigaciones Biomédicas (CRIB), Castilla-La Mancha University (UCLM), and Albacete University Hospital, Albacete, Spain. 2Faculty of Nursing, UCLM, Albacete, Spain.
López-Rosa R1*, Tébar-García D1*, Noblejas-López MM1, Nuncia-Cantarero N1, Nieto-Jiménez C1, Burgos M1 and Galán-Moya EM1,2
1Translational Research Unit, Centro Regional de Investigaciones Biomédicas (CRIB), Castilla-La Mancha University (UCLM), and Albacete University Hospital, Albacete, Spain. 2Faculty of Nursing, UCLM, Albacete, Spain.
Podoplanin-CD44-MT1 role in the modulation of invadopodia-mediated extracellular matrix degradation and invasiveness of squamous carcinoma (ID_ 33)
Montero-Montero L1,3, Parsons M2, Beltrán S3, Grueso E3, Jarcovski R3, Renart J1, Quintanilla M1 and Martín-Villar E1,3.
1Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain. 2Randall Division of Cell & Molecular Biophysics, King's College London, London, UK. 3Departamento de Biotecnología, Universidad Francisco de Vitoria, Madrid, Spain.
Montero-Montero L1,3, Parsons M2, Beltrán S3, Grueso E3, Jarcovski R3, Renart J1, Quintanilla M1 and Martín-Villar E1,3.
1Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain. 2Randall Division of Cell & Molecular Biophysics, King's College London, London, UK. 3Departamento de Biotecnología, Universidad Francisco de Vitoria, Madrid, Spain.
Role of TGFβ1 in combination with N-acetyl cysteine in the response of squamous cell carcinoma to photodynamic therapy (ID_ 28)
Gallego-Rentero, M.(1,2); Gutiérrez-Perez, M.(1); Portillo-Esnaola, M.(1,2); Najera, L.(3); Carrasco, E.(1,2); Juarranz, A.(1,2)
1: Universidad Autónoma de Madrid, Spain; 2: Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Madrid, Spain; 3: Hospital Universitario Puerta de Hierro, Majadahonda, Spain
Gallego-Rentero, M.(1,2); Gutiérrez-Perez, M.(1); Portillo-Esnaola, M.(1,2); Najera, L.(3); Carrasco, E.(1,2); Juarranz, A.(1,2)
1: Universidad Autónoma de Madrid, Spain; 2: Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Madrid, Spain; 3: Hospital Universitario Puerta de Hierro, Majadahonda, Spain
Stabilization of AMOT levels by the tankyrase inhibitor XAV939 restores the defective endothelial junction phenotype and YAP localization induced by TP73 knockdown (ID_ 51)
Alonso-Olivares H.1,2, Maeso-Alonso L.1,2, Villoch-Fernandez J. 1,2, Claesson-Welsh L.3, Fernández-Corona A.4 Marques M.M.5 & Marin M.C.1,2
1 Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana s/n, 24071, León, España; 2 Departamento de Biología Molecular, Universidad de León, Campus de Vegazana s/n, 24071, León, España; 3 Departament of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 752 36, Uppsala, Sweden; 4 Servicio de Ginecología, Complejo Asistencial Universitario de León (CAULE), C/ Altos de Nava s/n, 24071, León, España; 5 Departamento de Producción Animal, Universidad de León, Campus de Vegazana s/n, 24071, León, España.
Alonso-Olivares H.1,2, Maeso-Alonso L.1,2, Villoch-Fernandez J. 1,2, Claesson-Welsh L.3, Fernández-Corona A.4 Marques M.M.5 & Marin M.C.1,2
1 Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana s/n, 24071, León, España; 2 Departamento de Biología Molecular, Universidad de León, Campus de Vegazana s/n, 24071, León, España; 3 Departament of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 752 36, Uppsala, Sweden; 4 Servicio de Ginecología, Complejo Asistencial Universitario de León (CAULE), C/ Altos de Nava s/n, 24071, León, España; 5 Departamento de Producción Animal, Universidad de León, Campus de Vegazana s/n, 24071, León, España.
*TSQ fluorochrome incubation increase autometallographic zinc detection in primary cell cultures of astrocytes (ID_ 4)
Ballestín, R.; Torres, J.; Ponsoda, X
Cellular Neurobiology Research Unit, Cell Biology Department, Universitat de València, Doctor Moliner, 50, 46100 Burjassot, València, Spain
Ballestín, R.; Torres, J.; Ponsoda, X
Cellular Neurobiology Research Unit, Cell Biology Department, Universitat de València, Doctor Moliner, 50, 46100 Burjassot, València, Spain
β-catenin signaling mediates adipose tissue induced phenotype-switch in melanoma (ID_ 81)
Ramírez-Sánchez A.1, Sánchez-De la Cruz A.1, Gutiérrez-Salmerón M.1, García-Martínez JM.1, Fiuza C.2, De la Vieja A.3, García-Jiménez C.1, Chocarro-Calvo A.1.
1Universidad Rey Juan Carlos, Alcorcón, Madrid. 2Fundación Hospital Alcorcón, Alcorcón, Madrid. 3UFIEC, Instituto de Salud Carlos III, Majadahonda, Madrid
Ramírez-Sánchez A.1, Sánchez-De la Cruz A.1, Gutiérrez-Salmerón M.1, García-Martínez JM.1, Fiuza C.2, De la Vieja A.3, García-Jiménez C.1, Chocarro-Calvo A.1.
1Universidad Rey Juan Carlos, Alcorcón, Madrid. 2Fundación Hospital Alcorcón, Alcorcón, Madrid. 3UFIEC, Instituto de Salud Carlos III, Majadahonda, Madrid
Symposium 7: “Immunology”
Chairs:
Alberto Álvarez-Barrientos. Universidad de Extremadura. Spain
José Carlos Segovia. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT). Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)
Alberto Álvarez-Barrientos. Universidad de Extremadura. Spain
José Carlos Segovia. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT). Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)
Actin organization in corneal endothelial cells plays a key role in the structure and function of the layer. (ID_56)
Cerro-Tello,G; Benito-Martínez,S; Cacho-Navas,C; Barroso, S; de Rivas-Hidalgo, G; Millán, J
Centro de Biología Molecular Severo Ochoa-CSIC, UAM, Madrid, Madrid, Spain.
Cerro-Tello,G; Benito-Martínez,S; Cacho-Navas,C; Barroso, S; de Rivas-Hidalgo, G; Millán, J
Centro de Biología Molecular Severo Ochoa-CSIC, UAM, Madrid, Madrid, Spain.
Activation of the endogenous RhoA GTPase subfamily preserves endotelial barrier function in vitro and during local and systemic inflammation in viv0 (ID_ 27)
Colás-Algora, Natalia; Caballero, Alvaro; Cacho-Navas, Cristina; González-Fernández, Martín; Barroso, Susana; de Rivas-Hidalgo, Gema; Millán, Jaime
Centro de Biología Molecular Severo Ochoa-CSIC, Universidad Autónoma de Madrid, Spain.
Colás-Algora, Natalia; Caballero, Alvaro; Cacho-Navas, Cristina; González-Fernández, Martín; Barroso, Susana; de Rivas-Hidalgo, Gema; Millán, Jaime
Centro de Biología Molecular Severo Ochoa-CSIC, Universidad Autónoma de Madrid, Spain.
Activation-induced expression of non-muscle myosin IIB shapes lymphocyte polarity and the immune synapse and T cell activation (ID_23)
Millán-Salanova M1, Llorente-González C1, Blas-Rus N2, C. Talayero C1, N. Navarro M3, Vicente-Manzanares M1.
1Centro de Investigación del Cáncer - Instituto de Biología Molecular y Celular del Cáncer, CSIC, Salamanca.2 Universidad Autónoma de Madrid, School of Medicine, Madrid. 3 Centro de Biología Molecular Severo Ochoa, Campus UAM, Madrid.
Millán-Salanova M1, Llorente-González C1, Blas-Rus N2, C. Talayero C1, N. Navarro M3, Vicente-Manzanares M1.
1Centro de Investigación del Cáncer - Instituto de Biología Molecular y Celular del Cáncer, CSIC, Salamanca.2 Universidad Autónoma de Madrid, School of Medicine, Madrid. 3 Centro de Biología Molecular Severo Ochoa, Campus UAM, Madrid.
*AhR deficiency improves the cytokine network in the "priming phase” of the regeneration (ID_ 82)
Rejano-Gordillo C.M. & Fernández-Salguero P.M.
1Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain; 2Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Badajoz, Spain.
Rejano-Gordillo C.M. & Fernández-Salguero P.M.
1Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain; 2Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Badajoz, Spain.
Development of a cell model system to study food allergen-induced immune response (ID_ 53)
Parrón-Ballesteros, J., García-Gordo, R., Olmo, N., Villalba, M., Turnay, J.
Dpto. Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid
Parrón-Ballesteros, J., García-Gordo, R., Olmo, N., Villalba, M., Turnay, J.
Dpto. Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid
Effect of Sin a 1, the major allergen from mustard seeds, on a model system of intestinal epithelium (ID_ 64)
García-Gordo, R., Parrón-Ballesteros, J., Olmo, N., Villalba, M., Turnay, J.
Dpto. Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid
García-Gordo, R., Parrón-Ballesteros, J., Olmo, N., Villalba, M., Turnay, J.
Dpto. Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, Madrid
*Erythrocyte membrane proteins involved in host-parasite interaction in Plasmodium falciparum infection (ID_ 103)
Castro Salguedo C, Reyes Hernández M, Moneriz Pretell C
Bioquímica y Enfermedad investigation group. University of Cartagena. Cartagena-Colombia
Castro Salguedo C, Reyes Hernández M, Moneriz Pretell C
Bioquímica y Enfermedad investigation group. University of Cartagena. Cartagena-Colombia
Phenotype-genotype correlation of disease-inducing MYH9 variants at a cellular and single-molecule level (ID_ 22)
Llorente-González C1, Millán-Salanova M1, Heissler, S.M.2, Vicente-Manzanares M1
1 Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer, CSIC, Salamanca. 2 The Ohio State University, Columbus, OH, USA.
Llorente-González C1, Millán-Salanova M1, Heissler, S.M.2, Vicente-Manzanares M1
1 Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer, CSIC, Salamanca. 2 The Ohio State University, Columbus, OH, USA.
Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells (ID_52)
Cacho-Navas, C; López Pujante, C; Barroso, S; de Rivas-Hidalgo, G; Colás Algora N; Millán, J
Centro de Biología Molecular Severo Ochoa-CSIC, Universidad Autónoma de Madrid, Spain
Cacho-Navas, C; López Pujante, C; Barroso, S; de Rivas-Hidalgo, G; Colás Algora N; Millán, J
Centro de Biología Molecular Severo Ochoa-CSIC, Universidad Autónoma de Madrid, Spain
SOD3 inhibits LAMA5 expression in endothelial cells by interfering with the NF-kB pathway signaling (ID_6)
Mira E.1, Martinez-Rey D.1, Carmona-Rodríguez L.2 and Mañes S.1
1Department of Immunology and Oncology and 2Proteomics Unit, Centro Nacional de Biotecnología/CSIC, Madrid.
Mira E.1, Martinez-Rey D.1, Carmona-Rodríguez L.2 and Mañes S.1
1Department of Immunology and Oncology and 2Proteomics Unit, Centro Nacional de Biotecnología/CSIC, Madrid.
Symposium 8: “Aging, Senescence, Autophagy and Death”
Chairs:
Rosa M. Sainz. Instituto de Oncología de Asturias (IUOPA). Universidad de Oviedo. Oviedo. Spain
Patricia Boya. CIB. CSIC. Madrid. Spain
Rosa M. Sainz. Instituto de Oncología de Asturias (IUOPA). Universidad de Oviedo. Oviedo. Spain
Patricia Boya. CIB. CSIC. Madrid. Spain
Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration (ID_8)
Ramírez-Pardo I, Villarejo-Zori B, Jiménez-Loygorri JI, Sierra-Filardi E, Gómez-Sintes R* and Boya P
Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Madrid, Spain.
Ramírez-Pardo I, Villarejo-Zori B, Jiménez-Loygorri JI, Sierra-Filardi E, Gómez-Sintes R* and Boya P
Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Madrid, Spain.
AMBRA1 sustains retinal pigment epithelium homeostasis upon aging (ID_17)
Jiménez-Loygorri JI, Ramírez-Pardo I, Villarejo-Zori B, Sierra-Filardi E, Gómez-Sintes R and Boya P
Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Madrid, Spain
An aqueous extract from Polypodium leucotomos, Fernblock®, inhibits the formation of dark cyclobutane pyrimidine dimers in melanocytes exposed to UVA radiation (ID_ 15)
Portillo-Esnaola M1,2, Rodríguez-Luna A3, Terrén Gómez S1, Gallego-Rentero M1,2, González-Rodríguez S4, Juarranz A1,2.
1. Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM); 2. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28049 Madrid, Spain; 3. Innovation and Development, Cantabria Labs, 28043 Madrid, Spain; 4. Department of Medicine and Medical Specialties, Alcalá de Henares University, 28805 Madrid, Spain
Jiménez-Loygorri JI, Ramírez-Pardo I, Villarejo-Zori B, Sierra-Filardi E, Gómez-Sintes R and Boya P
Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Madrid, Spain
An aqueous extract from Polypodium leucotomos, Fernblock®, inhibits the formation of dark cyclobutane pyrimidine dimers in melanocytes exposed to UVA radiation (ID_ 15)
Portillo-Esnaola M1,2, Rodríguez-Luna A3, Terrén Gómez S1, Gallego-Rentero M1,2, González-Rodríguez S4, Juarranz A1,2.
1. Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM); 2. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28049 Madrid, Spain; 3. Innovation and Development, Cantabria Labs, 28043 Madrid, Spain; 4. Department of Medicine and Medical Specialties, Alcalá de Henares University, 28805 Madrid, Spain
Cell corpse removal is dependent autophagy during retinal neurogenesis (ID_31)
Villarejo-Zori, B., Zapata-Muñoz, J., Esteban-Martínez, L., Sierra-Filardi, E. and Boya, P.
Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain
Villarejo-Zori, B., Zapata-Muñoz, J., Esteban-Martínez, L., Sierra-Filardi, E. and Boya, P.
Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain
*In vivo and in vitro cardiac aging: developing of cellular aging models (ID_101)
García-Mendívil L1,2, Hernández-Bellido N1,2, Sánchez-Barat M1,2, Pérez-Zabalza M1,2, Garrido-Huéscar E1,2, Oliveros JC3, Torres-Pérez R3, Ramos-Marquès M1,2, Pueyo E1,2,4, Ordovás L1,2,5
1Biomedical Signal Interpretation and Computational Simulation group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza; 2BSICoS, IIS Aragón, Zaragoza; 3Bioinformatics for Genomics and Proteomics, National Center of Biotechnology-Spanish National Research Council, Madrid; 4Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza; 5ARAID Foundation, Zaragoza
García-Mendívil L1,2, Hernández-Bellido N1,2, Sánchez-Barat M1,2, Pérez-Zabalza M1,2, Garrido-Huéscar E1,2, Oliveros JC3, Torres-Pérez R3, Ramos-Marquès M1,2, Pueyo E1,2,4, Ordovás L1,2,5
1Biomedical Signal Interpretation and Computational Simulation group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza; 2BSICoS, IIS Aragón, Zaragoza; 3Bioinformatics for Genomics and Proteomics, National Center of Biotechnology-Spanish National Research Council, Madrid; 4Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza; 5ARAID Foundation, Zaragoza
Interaction between CYB5R3 overexpression and nicotinamide riboside supplementation on markers of autophagic signaling and mitochondrial function in mouse skeletal muscle: Sexual dimorphism (ID_72)
Sánchez-Mendoza L.M.1, Pérez-Sánchez C.1,3, Rodríguez-López S.1, Burón M.I.1, González-Reyes, J.A.1, Moreno JA.1,3 , López-Pedrera C.3,de Cabo R.2, Villalba J.M.1
1Department of Cell Biology, Physiology and Immunology, Faculty of Sciences, University of Córdoba, Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain. 2Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. 3Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), University of Cordoba, Córdoba, Spain.
Sánchez-Mendoza L.M.1, Pérez-Sánchez C.1,3, Rodríguez-López S.1, Burón M.I.1, González-Reyes, J.A.1, Moreno JA.1,3 , López-Pedrera C.3,de Cabo R.2, Villalba J.M.1
1Department of Cell Biology, Physiology and Immunology, Faculty of Sciences, University of Córdoba, Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain. 2Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. 3Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), University of Cordoba, Córdoba, Spain.
Sexual dimorphism in anti-aging interventions with NAD+ boosters and CYB5R3 overexpression. Effects on autophagy and mitochondria population in kidney (ID_55)
Pérez Rodríguez, M.; Sánchez Mendoza, L.M.; Burón Romero, M.I.; González Reyes, J.A., Villalba Montoro, J.M.
Department of Cell Biology, Physiology and Immunology, Rabanales Campus, University of Cordoba, Cordoba.
Pérez Rodríguez, M.; Sánchez Mendoza, L.M.; Burón Romero, M.I.; González Reyes, J.A., Villalba Montoro, J.M.
Department of Cell Biology, Physiology and Immunology, Rabanales Campus, University of Cordoba, Cordoba.
Small extracellular vesicles from young fibroblasts improve the antioxidant response and senescence in neurons and old mice brains (ID_35)
M. Posada-Gracia1, J. Alarcón-Gil1, J. Pascual-Guerra1, M.C. Nogales-Valenciano1, M. J. Ruiz de León1, J. Fafian-Labora2, A. O’Loghlen2, J.A. Rodríguez-Navarro1,3
1 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; 2 Queen Mary University of London, Epigenetics & Cellular Senescence Group, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdo; 3Universidad Complutense de Madrid (UCM), departamento de Biología Celular.
M. Posada-Gracia1, J. Alarcón-Gil1, J. Pascual-Guerra1, M.C. Nogales-Valenciano1, M. J. Ruiz de León1, J. Fafian-Labora2, A. O’Loghlen2, J.A. Rodríguez-Navarro1,3
1 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain; 2 Queen Mary University of London, Epigenetics & Cellular Senescence Group, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdo; 3Universidad Complutense de Madrid (UCM), departamento de Biología Celular.
THE PROHIBITIN-BINDING COMPOUND FLUORIZOLINE ACTIVATES p38 AND JNK (ID_48)
Ismael Sánchez-Vera1, José Saura-Esteller1, Sonia Núñez-Vázquez1, Ana M. Cosialls1, Rodolfo Lavilla2, Gabriel Pons1, Daniel Iglesias-Serret1,3*, Joan Gil1*. 1 Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain. 2Laboratory of Medical Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Medicine (IBUB), University of Barcelona, Barcelona, Spain. 3Facultat de Medicina. Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Vic, Barcelona, Spain. *Corresponding authors
Symposium 9: “Neuron and Glia Biology”
Chairs:
Teresa Iglesias. IIB-CSIC UAM. Madrid. Spain
Mario Durán. University of Castilla-La Mancha. Ciudad Real. Spain
Teresa Iglesias. IIB-CSIC UAM. Madrid. Spain
Mario Durán. University of Castilla-La Mancha. Ciudad Real. Spain
*Changes of Satb2 in the cerebral cortex of Syrian hamster during hibernation (ID_99)
Carballeira P., López Jesús M., Muñoz Alberto
Deparment of Cell Biology. Faculty of Biology of the Complutense University of Madrid.
Carballeira P., López Jesús M., Muñoz Alberto
Deparment of Cell Biology. Faculty of Biology of the Complutense University of Madrid.
Proteomic and transcriptomic analyses of the WIP-YAP/TAZ pathway in solid versus hematological tumors (ID_107)
Orantes A. 1,2,3, Rivas S. 1,2,3, Gómez C. 2,3, Wandosell F. 1,3 and Antón I.M. 2,3
1 CBMSO, Madrid; 2 CNB, Madrid; 3 CIBERNED, Madrid
Orantes A. 1,2,3, Rivas S. 1,2,3, Gómez C. 2,3, Wandosell F. 1,3 and Antón I.M. 2,3
1 CBMSO, Madrid; 2 CNB, Madrid; 3 CIBERNED, Madrid
Study of the physiological role of the scaffold protein SHOC2/Sur8 in the development of vertebrates and its implication in neurodegeneration (ID_84)
V. M. Cordero1, P. Palau1, D. Peña-Jiménez1, M. P de Lucas2, B. Anta2, J. L. Oliva2, A. Banzo1, M. I. García-González1, D. Sardón3, M. R. Baquero-Artigao1, J. M. Rojas2 and M. Yunta1
1Unidad de Investigación Biomédica, Universidad Alfonso X El Sabio, Villanueva de La Cañada, Madrid; 2Unidad de Biología Celular, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, Majadahonda, Madrid; 3Unidad de Senescencia Celular, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, Majadahonda, Madrid; 4Unidad de Anatomía Patológica, Hospital Clínico Veterinario, Universidad Alfonso X El Sabio, Villanueva de La Cañada, Madrid.
V. M. Cordero1, P. Palau1, D. Peña-Jiménez1, M. P de Lucas2, B. Anta2, J. L. Oliva2, A. Banzo1, M. I. García-González1, D. Sardón3, M. R. Baquero-Artigao1, J. M. Rojas2 and M. Yunta1
1Unidad de Investigación Biomédica, Universidad Alfonso X El Sabio, Villanueva de La Cañada, Madrid; 2Unidad de Biología Celular, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, Majadahonda, Madrid; 3Unidad de Senescencia Celular, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, Majadahonda, Madrid; 4Unidad de Anatomía Patológica, Hospital Clínico Veterinario, Universidad Alfonso X El Sabio, Villanueva de La Cañada, Madrid.
*Study of the sexual dimorphism in the pattern of cell death in brains of newborn piglets exposed to hypoxia-ischemia (ID_91)
Chillida, M1; Robertson, NJ2 & Alonso-Alconada, D1,2
1Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain; 2Institute for Women’s Health, University College London, London, UK
Chillida, M1; Robertson, NJ2 & Alonso-Alconada, D1,2
1Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain; 2Institute for Women’s Health, University College London, London, UK
Synaptic activity enhances mitochondrial bioenergetics by increasing iron metabolism in cortical neurons (ID_60)
Tena-Morraja P (1,2), Reina-Del pozo M (1) Martinez-Estrada O (1, 3) Soriano-Zaragoza F.X. (1,2)
1- CELLTEC-UB, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain; 2- Institute of Neurosciences, University of Barcelona, Barcelona, Spain. 3- Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
Tena-Morraja P (1,2), Reina-Del pozo M (1) Martinez-Estrada O (1, 3) Soriano-Zaragoza F.X. (1,2)
1- CELLTEC-UB, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain; 2- Institute of Neurosciences, University of Barcelona, Barcelona, Spain. 3- Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
Synaptic activity enhances mitochondrial bioenergetics in neurons independently of mitochondrial mass changes (ID_70)
Riqué-Pujol G.1,2, Martínez-Estrada O.M.1,3, Reina M.1, Soriano F.X.1,2
1Celltec UB, Department of Cell Biology, Physiology and Immunology, University of Barcelona. 2Institute of Neurosciences, University of Barcelona. 3Institute of Biomedicine, University of Barcelona
Riqué-Pujol G.1,2, Martínez-Estrada O.M.1,3, Reina M.1, Soriano F.X.1,2
1Celltec UB, Department of Cell Biology, Physiology and Immunology, University of Barcelona. 2Institute of Neurosciences, University of Barcelona. 3Institute of Biomedicine, University of Barcelona
*URB447-induced neuroprotection targets caspase-3 activation and apoptosis after neonatal ischemic brain injury (ID_92)
Alonso-Alconada, D1; Carloni, S2; Moro, M1; Crinelli, R2; Duranti, A2 & Balduini, W2
1 Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain ; 2 Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy
Alonso-Alconada, D1; Carloni, S2; Moro, M1; Crinelli, R2; Duranti, A2 & Balduini, W2
1 Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain ; 2 Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy