Perez-Montes C1, Garcia-Macia M2, Arévalo R1, Velasco A1, Leung E3, Reynisson J4, Santos-Ledo A1.
1INCyL, Departamento de Biología Celular y Patología, Universidad de Salamanca, Spain. 2IBFG, Departamento de Bioquímica, Universidad de Salamanca, Spain. 3Auckland Cancer Society Research Centre, University of Auckland, New Zealand. 4School of Pharmacy and Bioengineering, Keele University, United Kingdom.
Thursday, November 10th
11:15-12:30h Coffee break and posters
Anacardium occidentale extract promotes autophagy and protects against glycative stress derived cytotoxicity (ID_42)
Ponce-Mora A.1 Alarcón-Gil J.2, Méril-Mamert V3, Rodríguez-Navarro J.A2, Muriel Sylvestre3, Gerardo Cebrián-Torrejón3 and Bejarano E1*
1 Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain
2 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
3 Université des Antilles, Pointe-à-Pitre, France.
Anti-tumoral compound NNC-55-0396 affects autophagy at different levels through calcium signaling (ID_38)
Visa A, Alza L, Cantí C & Herreros J
Cell Calcium Signaling Lab, IRBLleida, University of Lleida, Lleida, Spain.
Autophagy as a central process regulating carbon storage in the new extremophilic microalga Chlamydomonas urium (ID_58)
Odriozola-Gil Y.1, Pérez-Pérez M. E.1, Mallén-Ponce M. J.1, Rubio A.2, Salas J.3, Martínez-Force E.3, Pérez-Pulido A. J.2 and Crespo J. L.1
1Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla, Spain. 2 Centro Andaluz de Biología del Desarrollo (CABD, UPO-CSIC). Sevilla, Spain.
3 Instituto de la Grasa (CSIC). Sevilla, Spain.
Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes (ID_26)
Ballesteros U.1, Etxaniz A.1, Iriondo M. N.1,Varela Y. R.1,Lázaro M.2, Montes R.L.1, Valle M.2, Goñi F.M.1, Alonso A.1
1Instituto Biofisika (CSIC, UPV/EHU) and Department of Biochemistry, University of the Basque Country, Leioa, Spain.
2Structural Biology Unit, Center for Cooperative Research in Biosciences, CIC bioGUNE, Derio, Spain.
Chaperone-Mediated Autophagy regulates muscle stem cell functions during muscle regeneration (ID_36)
Ramírez-Pardo I1,2, Campanario S1,2, Flández M1,2, Chavda B3, Marta Martinez-Vicente3, Isern J1,2, Cuervo AM3 & Muñoz-Cánoves P1,2*
1Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
2Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), E-08003 Barcelona, Spain.
3Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, EEUU.
Consequences of the decrease in EGF binding to EGFR in Mytotonic Dystrophy type 1 (ID_60)
Giménez-Bejarano A. 1,2, Alegre-Cortés E. 1,2, Uribe-Carretero E. 1,2,3, Paredes-Barquero M. 1,2, Canales-Cortés S. 1,2, Sánchez-Molinero L. 3, Domínguez-Rojo N. 1, Blanco-Benítez M. 3, Martínez-Chacón G. 1,2,3, Niso-Santano M. 1,2,3, González-Polo R. A. 1,2,3, Gómez-Suaga P. 1,2, Fuentes J. M. 1,2,3 and Yakhine-Diop S. M.S. 2,3
1Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Cáceres, Spain.
2Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Cáceres, Spain.
3Centro de Investigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Comunidad de Madrid, Spain.
Increased autophagy markers and mitochondrial impairment in type 1 diabetes (ID_4)
Canet F 1, Diaz-Pozo P 1, Abad-Jiménez Z 1, Falcón R 1, López-Domènech S 1, Martinez de Marañón A 1, Vezza T 1, Rocha M 1, Víctor VM1,2
1Department of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO 46017. Valencia, Spain.
2Department of Physiology, University of Valencia, 46010, Valencia, Spain.
Induction of autophagy/mitophagy through bioactive compounds from acorn cupule. Neuroprotective mechanisms (ID_64)
Canales-Cortés S 1,2, Lavado G3, Duque González G1, Paredes-Barquero M1,2, Alegre-Cortés E1,2, Gimenez-Bejarano A 1,2, Uribe-Carretero E1,2,4, Climent V5, Camello P.J. 6, Sánchez Molinero L1, Domínguez-Rojo N 1, Blanco-Benítez M1,4, Aiastui A 4,7,10, López de Munain A4,7,8,9,10,11, Gómez Suaga P 1,2,3, Niso-Santano M1,2,3, Yakhine-Diop S M.S.1,2,3, Cava R 3, Fuentes J.M1,2,3 and González-Polo Rosa A.,1,2,3.
1 Universidad de Extremadura, Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain, 2 Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain, 3Universidad de Extremadura, INBio G-C, Departamento Facultad de Veterinaria, Cáceres, Spain 4 Centro de Univestigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Spain, 5 Universidad de Extremadura, Departmento de Anatomía y Embriología Humana, Facultad de Medicina, Badajoz, Spain, 6Universidad de Extremadura, Departamento de Fisiología, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain, 7 Cell Culture Plataform, Donostia University Hospital, San Sebastián, Spain,8 Neuroscience Area of Biodonostia Health Research Institute, Donostia University Hospital, San Sebastián, Spain, 9 Donostia University Hospital, Department of Neurology, San Sebastian, Spain, 10 Ilundain Foundation, San Sebastian, Spain, 11 Department of Neurosciences, University of the Basque Country UPV-EHU, San Sebastián, Spain
Mitophagy boosting protects cells against MNU toxicity (ID_30)
Zapata-Muñoz, J., Villarejo-Zori, B., Sierra-Filardi, E., Ramirez-Pardo, I. and Boya, P.
Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Madrid.
Novel small molecule antioxidants improve stress-induced cell reprogramming while decrease autophagy and cell death in rapeseed: a physiology and transcriptomics study (ID_62)
Rueda-Varela C, Carneros E, Pérez-Pérez Y, Caro E, Gil C, Martínez A, Testillano PS
1Pollen Biotechnology of Crop Plants group, 3Translational Medicinal and Biological Chemistry group, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid.
2Centre for Plant Biotechnology and Genomics, UPM-INIA-CSIC, Pozuelo de Alarcón
Reduced systemic autophagy by simultaneous loss of ATG4B, ATG4C and ATG4D leads to premature death in mice (ID_52)
Tamargo-Gómez I., Martínez-García G.G., Suárez MF., Fernández A.F., Mariño G.
Departamento de Biología Funcional, Universidad de Oviedo and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, SPAIN
Regulation of autophagy by the CPT1C-SAC1 complex in neurons (ID_48)
Fadó R1,2, Wenzel EM3,4, Raiborg C3,4, Stenmark H3,4 and Casals N1,2
1. Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Josep Trueta S/N, 08195, Sant Cugat del Vallès, Barcelona, Spain.
2. Centro de Investigación Biomédica en Red de Fisiopatología de La Obesidad Y La Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.
3. Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379, Oslo, Norway.
4. Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379, Oslo, Norway.
SIRT1-dependent autophagy as a novel therapy for age-related memory decline (ID_44)
Romeo-Guitart, D., Mailliet F., Rivagorda, M., Boitez, V., Oury, F.
Laboratory Hormonal Regulation of Brain Development and Functions-Team 8, Institut Necker Enfants-Malades (INEM), INSERM U1151, Université Paris Descartes, Sorbonne Paris Cité, 75015 Paris, France
17:00-18:15h Coffee Break and posters
Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration (ID_39)
Villarejo-Zori B1*, Ramírez-Pardo I1*, Jiménez-Loygorri JI1, Sierra-Filardi E1, Alonso-Gil S1, Gómez-Sintes R1* and Boya P1*
1 Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Madrid, Spain.
AMPK activation is not enough to boost autophagy in primary neural cells (ID_3)
García-Juan M., Benito-Cuesta I., Ordóñez-Gutiérrez L. and Wandosell F.
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid
ATG4B mediates beta-catenin expression and 3D spheroid formation in pancreatic ductal adenocarcinoma (ID_65)
Aley N, Trugenberger C, Gasparaviciute A, Singh N and Ketteler R.
MRC Laboratory for Molecular Cell Biology, University College London, UK
Autophagy deregulation differs between muscle and motoneurons in Spinal Muscular Atrophy (ID_47)
Garcerá A, Sansa A, Miralles MP, Beltran M, and Soler RM
Neuronal Signaling Unit, Dept. Medicina Experimental, Universitat de Lleida-IRBLleida
Autophagy modulation in glial cells infected with herpes simplex virus type 1 (ID_53)
Inés Ripa1,2, Sabina Andreu1,2, José Antonio López-Guerrero1,2, Raquel Bello-Morales1,2
1Department of Molecular Biology, Universidad Autónoma de Madrid, Madrid, Spain
2Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, Spain
Ceramide enhances the binding of LC3/GABARAP autophagy proteins to lipid membranes (ID_25)
Varela Y. R. 1, Iriondo M. N. 1, Gonzalez-Ramirez E. J. 1, Etxaniz A. 1, Ballesteros U. 1, Goñi F. M. 1, Alonso A.1
1Instituto Biofisika (UPV/EHU-CSIC), Leioa (Biscay)
Chaperone mediated autophagy as therapeutic target in retina in Parkinson’s disease (ID_33)
Raquel Gómez-Sintes1,2, Adrián Martín-Segura2, Inmaculada Tasset-Cuevas2, María Martín-Bartolomé1, Sandra Alonso-Gil1, Ana María Cuervo2,3, Patricia Boya1.
1Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
2Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY
3 Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY.
Characterization of proteins functionally related to Wdr45l in Dictyostelium (ID_49)
Antón-Esteban L., Collado L, Vincent, O. and Escalante, R.
Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, Spain
Impairment of autophagy in plasmanylethanolamine desaturase-deficient cells (ID_45)
M. Posada-Gracia1, J. Alarcón-Gil1, M. J. Asensio1, Nogales M.D.C.1, M. J. Casarejos1, E. Bastida-Martínez2, M. Elías-Arnanz2, J.A. Rodríguez-Navarro1,3
1 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain 2 Departamento de Genética y Microbiología, Área de Genética (Unidad Asociada al Instituto de Química Física “Rocasolano”, Consejo Superior de Investigaciones Científicas), Facultad de Biología, Universidad de Murcia, Murcia 30100, Spain
3Universidad Complutense de Madrid (UCM), departamento de Biología Celular
Implication of SIRT1 axis in Queen Bee Acid-induced autophagy (ID_61)
Paredes-Barquero M.1,2,*, Martínez-Chacón G.1,2,3, Alegre-Cortés E.1,2, Canales- Cortés S.1,2, Gimenez-Bejarano A.1,2, Uribe-Carretero E.1,2,3, Sánchez-Molinero L.1,3, Domínguez-Rojo N.1, Blanco-Benítez M.1,3 Gómez-Suaga P.1,2, Yakhine-Diop SMS.2,3, González-Polo RA.1,2,3, Fuentes JM.1,2,3, Niso-Santano M.1,2,3
1Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Spain.
2Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain.
3Centro de Investigación Biomédica en Red de Enfermedades (CIBERNED), Madrid,
Spain.
THE PARKINSONIAN LRRK2 R1441G MUTATION SHOWS MACROAUTOPHAGY-MITOPHAGY DYSREGULATION CONCOMITANT WITH ENDOPLASMIC RETICULUM STRESS
EFFECT OF LRRK2 R1441G MUTATION ON THE MECHANISM OF AUTOPHAGY IN HUMAN CELLS FROM PARKINSON'S PATIENTS (ID_31)
Saray Canales-Cortés1, Mario Rodríguez-Arribas1, Guadalupe Martínez-Chacón1,2,3, Gema Duque González1, Marta Paredes-Barquero1, Eva Alegre-Cortés1, Elisabet Uribe-Carretero1,2,3, Ana Calderón1, Alberto Gimenez-Bejarano1,2, Patricia Gómez Suaga1,2, Mercedes Blanco-Benítez1, Vicente Climent4, Ana Aiastui3,5,8, Adolfo Lopez de Munain3,7,8,9, José M. Bravo-San Pedro3,10, Mireia Niso-Santano1,2,3, José M. Fuentes1,2,3, Sokhna M.S. Yakhine-Diop1,2,3, Rosa A. González-Polo1,2,3.
1 Universidad de Extremadura, Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain,
2 Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain,
3 Centro de Univestigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Spain,
4 Universidad de Extremadura, Departmento de Anatomía y Embriología Humana, Facultad de Medicina, Badajoz, Spain,
5 Cell Culture Plataform, Donostia University Hospital, San Sebastián, Spain,
6 Neuroscience Area of Biodonostia Health Research Institute, Donostia University Hospital, San Sebastián, Spain,
7 Donostia University Hospital, Department of Neurology, San Sebastian, Spain,
8 Ilundain Foundation, San Sebastian, Spain,
9 Department of Neurosciences, University of the Basque Country UPV-EHU, San Sebastián, Spain,
10 Complutense University of Madrid, Faculty of Medicine, Department of physiology, Madrid, Spain
Unveiling the role of autophagy in the chloroplast stress response in the model microalga Chlamydomonas reinhardtii (ID_57)
Gámez-Arcas S.1, Heredia-Martínez L. G. 1, Mallén-Ponce M. J.1, Crespo J. L.1 and Pérez-Pérez M. E.1
1Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla, Spain.