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         Oral Communications      

Wednesday, November 9th
16:30-17:30h         Session 1 “Physiological Roles of Autophagy”
Chair: Guillermo Velasco
 
16:30-16:50h Role of autophagy during cell competition in heart development and regeneration
Esteban-Martínez L, Sierra R, Torres M.
Spanish National Centre for Cardiovascular Research, Madrid.
16:50-17:10h An alternative metabolic link connects glutamine and autophagy to control glutamoptosis
Bodineau C1, Tomé M1, Costa ASH2, Murdoch PS1, Frezza C2 and Durán RV1
1 Centro Andaluz de Biología Molecular y Medicina Regenerativa - CABIMER, Consejo Superior de Investigaciones Científicas - Universidad de Sevilla - Universidad Pablo de Olavide, Avda. Américo Vespucio 24, 41092 Seville, Spain
2 Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MR Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK
17:10-17:30h Post-ER degradation of misfolded GPI-anchored proteins is linked with microautophagy
Leticia Lemus1*, Zrinka Matić 1, Lihi Gal 2, Amir Fadel 2, Maya Schuldiner 2, Veit Goder 1*
1 Department of Genetics, University of Seville, Ave Reina Mercedes, 6, 41012 Seville, Spain.
2 Department of Molecular Genetics, Meyer Bldg. Room 122, Weizmann Institute of Sciences, 76100 Rehovot, Israel.
 
18:00-19:00h         Session 2 “Physiological Roles of Autophagy”
Chair: Nadeza Apostolova
 
18:00-18:20h Functional differences in microglial and neuronal macroautophagy under proteotoxic stress
Ruano D.1,2 and Domínguez-Martín H.1,2
1. Instituto de Biomedicina de Sevilla (IBiS).
2.
Departamento de Bioquímica y Biología Molecular. Facultad de Farmacia. Universidad de Sevilla
18:20-18:40h  cAMP-Protein Kinase A and Stress-Activated MAP signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation
Pérez-Díaz, A. J; Vázquez-Marín, B.; Vicente-Soler, J.; Prieto-Ruiz, F.; Soto, T.; Franco, A.; Cansado, J. and Madrid, M.
Department of Genetics and Microbiology. Campus de Excelencia Internacional de Ámbito Regional (CEIR) Campus Mare Nostrum, Universidad de Murcia. Murcia, Spain.
18:40-19:00 h Finding Nemo: discovering novel autophagy modulators with ebrafish

Perez-Montes C1, Garcia-Macia M2, Arévalo R1, Velasco A1, Leung E3, Reynisson J4, Santos-Ledo A1.

 1INCyL, Departamento de Biología Celular y Patología, Universidad de Salamanca, Spain. 2IBFG, Departamento de Bioquímica, Universidad de Salamanca, Spain. 3Auckland Cancer Society Research Centre, University of Auckland, New Zealand. 4School of Pharmacy and Bioengineering, Keele University, United Kingdom.

 
Thursday, November 10th
10:00-11:00h       Session 3
Chair: Raúl Durán
Physiological Roles of Autophagy”
10:00-10:20h Photosynthetic assimilation of CO2 regulates TOR activity
Mallén-Ponce M. J.1, Pérez-Pérez M. E.1 and Crespo J. L.1
1Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla, Spain
“Autophagy and Disease”
10:20-10:40h Role of autophagy in the hepatoprotective role of the antiretroviral drug Rilpivirine: when less is more
Lucantoni Fa,b, Benedicto AMa, Gruevska Aa,b, Moragrega ABa,b, Fuster-Martínez Ia, Esplugues JVa,b,c, Blas-García Ab,c,d and Apostolova Aa,b,c*
aDepartamento de Farmacología, Facultad de Medicina, Universidad de Valencia, Valencia
bFISABIO–Hospital Universitario Dr. Peset, Valencia
cCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Valencia
dDepartamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia
10:40-11:00h Selective autophagy plays a protective role against acute and age-related retinal degeneration
Jiménez-Loygorri JI1, Ramírez-Pardo I1, Villarejo-Zori B1, Viedma-Poyatos A1, Sierra-Filardi E1, Gómez-Sintes R1 and Boya P1
1 Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Madrid, Spain.
 
12:40-13:40h       Session 4 “Autophagy and Disease”
Chair: José Manuel Fuentes
 
12:40-13:00h Characterization of the molecular mechanism of autophagy inhibition by HER2
Jetsy Karina Montero Vergara1, Verena Jendrossek1, Silvia Vega-Rubín-de-Celis1,*
1Institute for Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, Germany
13:00-13:320h Dysregulation of the autophagic-lysosomal pathway in Parkinson’s disease associated to GBA
E. Pradas-Gracia1, A. Navarro-Romero1, I. Fernandez-Gonzalez1, M. Montpeyo1, J. Riera1, J.A. Arranz2, C. Carnicer-Caceres2, L. Castillo1-2, D. Montpeyo3, P. Sarlé3, F. Novio3, J. Lorenzo3, M. Martinez-Vicente1.
1: Vall d'Hebron Research Institute (VHIR), Neurodegenerative Diseases, Barcelona, Spain
2: Hospital Universitari Vall d'Hebron, Biochemistry Service, Barcelona, Spain
3: Autonomous University of Barcelona, Bellaterra, Spain
13:20-13:40h  Does AMBRA-1 play onco-suppressive functions in skin squamous cell carcinomas?
Gabicagogeascoa E1,2, Lorente M1,2, Salvador N1,2, Saiz-Ladera C1,2, Hill D3, Salazar-Roa M1, Orea-Soufi A1,2, García-Taboada E1,2, Boya P4, Herrera B5, Sánchez-Muñoz A5, Lovat P3 and Velasco G1,2.
1 Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain
2 Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
3 Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK
4 Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
5 Department of Biochemistry and Molecular Biology, School of Pharmacy, Complutense University, Madrid, Spain
 
15:30-17:00h   Session 5  "Junior PI Symposium and WIA Presentation"
Chair: Patricia Boya
 
15:30-15:50h Microvascular endothelial cell autophagy regulates neutrophil trafficking in inflammation
Reglero-Real N1,7*, Pérez-Gutiérrez L1,7, Yoshimura A2, Rolas L1, Barkaway A1, Boulanger C3, Muller WA4, Nightingale TD1, Perretti M5, Tooze SA6, Collinson L2, Aksoy E6 and Nourshargh S1*
1Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 2Electron Microscopy Science Technology Platform, Francis Crick Institute ,London, 3INSERM, Paris Cardiovascular Research Centre, Paris, 4Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, 5Centre for Biochemical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 6Molecular Cell Biology of Autophagy Laboratory, Francis Crick Institute, London, 7These authors contributed equally
15:50-16:10h Control of mitosis by lysosomes to develop CIN-targeting cancer therapy
Mauvezin C
Department of Biomedicine, Faculty of Medicine, Universitat de Barcelona, Barcelona
16:10-16:30h Anacardium occidentale extract promotes autophagy and protects against glycative stress derived cytotoxicity
Ponce-Mora A.1 Alarcón-Gil J.2, Méril-Mamert V3, Rodríguez-Navarro J.A2, Muriel Sylvestre3, Gerardo Cebrián-Torrejón3 and Bejarano E1*
1 Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain
2 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
3 Université des Antilles, Pointe-à-Pitre, France.
16:30-16:50h A mammalian target of rapamycin-perilipin3 (mTORC1-Plin3) pathway is essential to activate lipophagy and protects against hepatosteatosis
Santos-Ledo A1, Leslie J2, Paish H2, Collins A2, Scott R2, Watson A2, Burgoyne R2, White S3, French J3, Hammond J3, Borthwick L2, Mann J2, Bolaños JP4,5, Korolchuk V2, Oakley F2, Mann D2, Garcia-Macia M4,5
1University of Salamanca, INCYL, Salamanca, Spain. 2Newcaslte University, Biosciences Institute, Newcastle Upon Tyne, United Kingdom. 3Newcastle upon Tyne Hospitals NHS Foundation Trust, Department of Hepatobiliary Surgery, Newcastle Upon Tyne, United Kingdom. 4IBSAL, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain. 5University of Salamanca, Institute of Functional Biology and Genomics, Salamanca, Spain
 
18:15-19:15h       Session 6 “Autophagy and Disease
Chair: Ricardo Escalante
 
18:15-18:35h Differential process of mitophagy in neurons and astrocytes associated to Parkinson’s disease related to a-synuclein
Lastres-Becker, I.1,2, Castro- Sánchez1, S. Silva-Llanes1, I., Teresak3, P., Lanciego, J.L. 4, Sierra, E. 3, Boya, P3.
1Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Arturo Duperier,4 Madrid, Spain. Department of Biochemistry, School of Medicine, Universidad Autónoma de Madrid, Spain. Institute Teófilo Hernando for Drug Discovery, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
2Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid (Spain)
3Centro de Investigaciones Biológicas Margarita Salas, CSIC. Ramiro de Maeztu 9, 28040, Madrid, Spain.
4Department of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pio XII Ave 55, Edificio CIMA, 31008, Pamplona, Navarra, Spain.
18:35-18:55h Deciphering the formation and clearance of glycogen aggregates in Lafora disease
Pellegrini P.1, Varea O.1, Guinovart J.J.1 , Duran J.1, 2, 3
1Institute for Research in Biomedicine (IRB Barcelona), Barcelona
2Institut Químic de Sarrià (IQS), Universitat Ramon Llull (URL), Barcelona
3Institute for Bioengineering of Catalonia (IBEC), Barcelona
18:55-19:15 Targeting autophagy vulnerabilities for cancer treatment
Vega-Rubín-de-Celis, Silvia1,*, Kudla, Matthias1, Montero-Vergara, Jetsy1, Jendrossek, Verena1, Peña-Llopis, Samuel2.
1 Institute for Cell Biology (Cancer Research), Essen University Hospital, Essen, Germany.
2 German Cancer Consortium (DKTK), Essen University Hospital, Essen, Germany.
 
Friday, November 11th
10:00-11:20h       Session 7 
Chair: José Luis Crespo
“Autophagy and Disease”
10:00-10:20h Astrocyte-derived small extracellular vesicles exert a protective effect on  euron and astrocytes primary cultures damaged with epoxomicin
Alarcon-Gil J.1, Posada-Gracia M.1, Nogales M.D.C.1, Escobar-Peso A.1, Ponce-Mora A.3, Casarejos M.J.1, Gómez A.1, Asensio M.J.1, Yuste A.3, O´Loghlen A.2, Bejarano E.3 and Rodríguez-Navarro J.A.1
1 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
2 Queen Mary University of London, Epigenetics & Cellular Senescence Group, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom.
3 School of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Valencia, Spain.
10:20-10:40h Diabetes type 3: role of human amylin and therapeutic approaches
González-Blanco C1, Lockwood A.1, Burillo J.1, Marqués P.1, B. Jiménez B. 1,2, García G.1,2, Benito M.1, Guillén C.1, 2.
1Dpto. de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid.
2CIBERDEM, CIBER de Diabetes y Enfermedades Metabólicas, ISCiII
“Mechanisms of Autophagy”
10:40-11:00h Molecular mechanisms of the interaction between the PROPPIN Atg21 and Atg16
Bueno-Arribas M., Cruz-Cuevas C., Navas M.A.*, Escalante R., Vincent O.
Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, Spain
* Departamento de Bioquímica y Biología Molecular, Facultad de Medicina,
Universidad Complutense de Madrid, Madrid, Spain.
11:00-11:20h TP53INP2 regulates selective autophagy
Saška Ivanova1,2,3, Sandra Macedo Ribeiro4, Marta Martinez-Vicente5, and Antonio Zorzano1,2,3
1 Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
2 CIBER de Diabetes y Enfermedades Metabolicas Asociadas, Barcelona, Spain
3 Departamento de Bioquimica, Biomedicina Molecular, Facultat de Biologia, Universidad de Barcelona, Barcelona, Spain
4 Instituto de Biologia Molecular e Celular – IBMC, Porto, Portugal
5 VHIR, Barcelona, Spain
 
12:20-13:40h       Session 8 
Chair: Marta Martínez
 
Mechanisms of Autophagy”
12:20-12:40h H2S regulates selective ER-phagy and mitophagy through persulfidation
Angeles Aroca, Cecilia Gotor
Instituto de Bioquímica Vegetal y Fotosíntesis (Universidad de Sevilla, Consejo Superior de Investigaciones Científicas), Américo Vespucio, 41092, Sevilla, Spain.
“Chaperone-Mediated Autophagy”
12:40-13:00h Chaperone-mediated autophagy controls proteomic and transcriptomic pathways to maintain glioma stem cell activity
Ander Matheu1, Jaione Auzmendi-Iriarte1, Maddalen Otaegi-Ugartemendia1, Felix Elortza2, Ana Maria Cuervo3,
1 Cellular Oncology group, Biodonostia Health Research Institute, San Sebastian, Spain
2 Proteomics Platform, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bilbao, Spain
3 Department of Development and Molecular Biology, Albert Einstein College of Medicine; Institute for Aging Studies, Albert Einstein College of Medicine, NY, USA.
13:00-13:20h Role of pericytes´ chaperone-mediated autophagy in tissue repair after injury/inflammatory damage
Salinas M.D.1,2,3; Molina M.L.1,4; Martínez C.5; Martínez S.4; Moraleda J.M.3,6; Valdor R.1,2,3
1Unit of Autophagy, Immune response and Tolerance in Pathologic Processes, Biomedical Research Institute of Murcia-Virgen de la Arrixaca (IMIB), 30120, Murcia, Spain.
2Biochemistry, Molecular Biology B, and Immunology Department, University of Murcia (UMU), 30120, Murcia, Spain.
3Cell Therapy and Hematopoietic Transplant Group-Internal Medicine Department, UMU, 30120,Murcia, Spain.
4Instituto de Neurociencias-University Miguel Hernández (UMH-CSIC), 03550, San Juan de Alicante, Spain.
5.Pathology Unit. IMIB. 30120, Murcia, Spain.
6.¨Virgen de la Arrixaca¨ Hospital; Cell therapy and HPT group, IMIB, 30120, Murcia, Spain.
13:20-13:40h Dissecting the regulation of CMA in a natural model of impaired glucose homeostasis, the rainbow trout
Vélez E.J.1, Schnebert S. 1, Goguet M. 1, Balbuena-Pecino S. 1, Dias K. 1, Beauclair L. 1, Véron V. 1, Depincé A. 2, Beaumatin F. 1, Herpin A. 2, Seiliez I1.
1Université de Pau et des Pays de l’Adour, E2S UPPA, INRAE, UMR1419 Nutrition Métabolisme et Aquaculture, Saint-Pée-sur-Nivelle, France. 2INRAE, UR1037 Laboratory of Fish Physiology and Genomics, Rennes, France. 
 
 
 
  Poster Communications     

 

Thursday, November 10th

11:15-12:30h       Coffee break and posters

 

Anacardium occidentale extract promotes autophagy and protects against glycative stress derived cytotoxicity (ID_42)

Ponce-Mora A.1 Alarcón-Gil J.2, Méril-Mamert V3, Rodríguez-Navarro J.A2, Muriel Sylvestre3, Gerardo Cebrián-Torrejón3 and Bejarano E1*

1 Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain

2 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.

3 Université des Antilles, Pointe-à-Pitre, France.

 

Anti-tumoral compound NNC-55-0396 affects autophagy at different levels through calcium signaling (ID_38)

Visa A, Alza L, Cantí C & Herreros J

Cell Calcium Signaling Lab, IRBLleida, University of Lleida, Lleida, Spain.

 

Autophagy as a central process regulating carbon storage in the new extremophilic microalga Chlamydomonas urium (ID_58)

Odriozola-Gil Y.1, Pérez-Pérez M. E.1, Mallén-Ponce M. J.1, Rubio A.2, Salas J.3, Martínez-Force E.3, Pérez-Pulido A. J.2 and Crespo J. L.1

1Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla, Spain. 2 Centro Andaluz de Biología del Desarrollo (CABD, UPO-CSIC). Sevilla, Spain.

3 Instituto de la Grasa (CSIC). Sevilla, Spain.

 

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes (ID_26)

Ballesteros U.1, Etxaniz A.1, Iriondo M. N.1,Varela Y. R.1,Lázaro M.2, Montes R.L.1, Valle M.2, Goñi F.M.1, Alonso A.1

1Instituto Biofisika (CSIC, UPV/EHU) and Department of Biochemistry, University of the Basque Country, Leioa, Spain.

2Structural Biology Unit, Center for Cooperative Research in Biosciences, CIC bioGUNE, Derio, Spain.

 

Chaperone-Mediated Autophagy regulates muscle stem cell functions during muscle regeneration (ID_36)

Ramírez-Pardo I1,2, Campanario S1,2, Flández M1,2, Chavda B3, Marta Martinez-Vicente3, Isern J1,2, Cuervo AM3 & Muñoz-Cánoves P1,2*  

1Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

2Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), E-08003 Barcelona, Spain.

3Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, EEUU.

 

Consequences of the decrease in EGF binding to EGFR in Mytotonic Dystrophy type 1 (ID_60)

Giménez-Bejarano A. 1,2, Alegre-Cortés E. 1,2, Uribe-Carretero E. 1,2,3, Paredes-Barquero M. 1,2, Canales-Cortés S. 1,2, Sánchez-Molinero L. 3, Domínguez-Rojo N. 1, Blanco-Benítez M. 3, Martínez-Chacón G. 1,2,3, Niso-Santano M. 1,2,3, González-Polo R. A. 1,2,3, Gómez-Suaga P. 1,2, Fuentes J. M. 1,2,3 and Yakhine-Diop S. M.S. 2,3

1Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Cáceres, Spain.

2Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Cáceres, Spain.

3Centro de Investigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Comunidad de Madrid, Spain.

 

Increased autophagy markers and mitochondrial impairment in type 1 diabetes (ID_4)

Canet F 1, Diaz-Pozo P 1, Abad-Jiménez Z 1, Falcón R 1, López-Domènech S 1, Martinez de Marañón A 1, Vezza T 1, Rocha M 1, Víctor VM1,2

1Department of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO 46017. Valencia, Spain.

2Department of Physiology, University of Valencia, 46010, Valencia, Spain.

 

Induction of autophagy/mitophagy through bioactive compounds from acorn cupule. Neuroprotective mechanisms (ID_64)

Canales-Cortés  S 1,2, Lavado G3, Duque González G1, Paredes-Barquero M1,2, Alegre-Cortés E1,2, Gimenez-Bejarano A 1,2, Uribe-Carretero E1,2,4, Climent V5, Camello P.J. 6, Sánchez Molinero L1, Domínguez-Rojo N 1, Blanco-Benítez M1,4, Aiastui A 4,7,10, López de Munain A4,7,8,9,10,11, Gómez Suaga P 1,2,3, Niso-Santano M1,2,3, Yakhine-Diop S M.S.1,2,3, Cava R 3, Fuentes J.M1,2,3 and González-Polo Rosa A.,1,2,3.

1 Universidad de Extremadura, Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain, 2 Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain, 3Universidad de Extremadura, INBio G-C, Departamento Facultad de Veterinaria, Cáceres, Spain 4 Centro de Univestigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Spain,  5 Universidad de Extremadura, Departmento de Anatomía y Embriología Humana, Facultad de Medicina, Badajoz, Spain, 6Universidad de Extremadura, Departamento de Fisiología, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain, 7 Cell Culture Plataform, Donostia University Hospital, San Sebastián, Spain,8 Neuroscience Area of Biodonostia Health Research Institute, Donostia University Hospital, San Sebastián, Spain, 9 Donostia University Hospital, Department of Neurology, San Sebastian, Spain, 10 Ilundain Foundation, San Sebastian, Spain,  11 Department of Neurosciences, University of the Basque Country UPV-EHU, San Sebastián, Spain

 

Mitophagy boosting protects cells against MNU toxicity (ID_30)

Zapata-Muñoz, J., Villarejo-Zori, B., Sierra-Filardi, E., Ramirez-Pardo, I. and Boya, P.

Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Madrid.

 

Novel small molecule antioxidants improve stress-induced cell reprogramming while decrease autophagy and cell death in rapeseed: a physiology and transcriptomics study (ID_62)

Rueda-Varela C, Carneros E, Pérez-Pérez Y, Caro E, Gil C, Martínez A, Testillano PS

1Pollen Biotechnology of Crop Plants group, 3Translational Medicinal and Biological Chemistry group, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid.

2Centre for Plant Biotechnology and Genomics, UPM-INIA-CSIC, Pozuelo de Alarcón

 

Reduced systemic autophagy by simultaneous loss of ATG4B, ATG4C and ATG4D leads to premature death in mice (ID_52)

Tamargo-Gómez I., Martínez-García G.G., Suárez MF., Fernández A.F., Mariño G.

Departamento de Biología Funcional, Universidad de Oviedo and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, SPAIN

 

Regulation of autophagy by the CPT1C-SAC1 complex in neurons (ID_48)

Fadó R1,2, Wenzel EM3,4, Raiborg C3,4, Stenmark H3,4 and Casals N1,2

1. Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Josep Trueta S/N, 08195, Sant Cugat del Vallès, Barcelona, Spain.

2. Centro de Investigación Biomédica en Red de Fisiopatología de La Obesidad Y La Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.

3. Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379, Oslo, Norway.

4. Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379, Oslo, Norway.

 

SIRT1-dependent autophagy as a novel therapy for age-related memory decline (ID_44)

Romeo-Guitart, D., Mailliet F., Rivagorda, M., Boitez, V., Oury, F.

Laboratory Hormonal Regulation of Brain Development and Functions-Team 8, Institut Necker Enfants-Malades (INEM), INSERM U1151, Université Paris Descartes, Sorbonne Paris Cité, 75015 Paris, France

 

 

 

17:00-18:15h       Coffee Break and posters

Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration (ID_39)

Villarejo-Zori B1*, Ramírez-Pardo I1*, Jiménez-Loygorri JI1, Sierra-Filardi E1, Alonso-Gil S1, Gómez-Sintes R1* and Boya P1*

1 Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Madrid, Spain.

 

AMPK activation is not enough to boost autophagy in primary neural cells (ID_3)

García-Juan M., Benito-Cuesta I., Ordóñez-Gutiérrez L. and Wandosell F.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid

Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid

 

ATG4B mediates beta-catenin expression and 3D spheroid formation in pancreatic ductal adenocarcinoma (ID_65)

Aley N, Trugenberger C, Gasparaviciute A, Singh N and Ketteler R.

MRC Laboratory for Molecular Cell Biology, University College London, UK

 

Autophagy deregulation differs between muscle and motoneurons in Spinal Muscular Atrophy (ID_47)

Garcerá A, Sansa A, Miralles MP, Beltran M, and Soler RM

Neuronal Signaling Unit, Dept. Medicina Experimental, Universitat de Lleida-IRBLleida

 

Autophagy modulation in glial cells infected with herpes simplex virus type 1 (ID_53)

Inés Ripa1,2, Sabina Andreu1,2, José Antonio López-Guerrero1,2, Raquel Bello-Morales1,2

1Department of Molecular Biology, Universidad Autónoma de Madrid, Madrid, Spain

2Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, Spain

 

Ceramide enhances the binding of LC3/GABARAP autophagy proteins to lipid membranes (ID_25)

Varela Y. R. 1, Iriondo M. N. 1, Gonzalez-Ramirez E. J. 1, Etxaniz A. 1, Ballesteros U. 1, Goñi F. M. 1, Alonso A.1

1Instituto Biofisika (UPV/EHU-CSIC), Leioa (Biscay)

 

Chaperone mediated autophagy as therapeutic target in retina in Parkinson’s disease (ID_33)

Raquel Gómez-Sintes1,2, Adrián Martín-Segura2, Inmaculada Tasset-Cuevas2, María Martín-Bartolomé1, Sandra Alonso-Gil1, Ana María Cuervo2,3, Patricia Boya1.

 1Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

2Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY

 3 Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY.

 

Characterization of proteins functionally related to Wdr45l in Dictyostelium (ID_49)

Antón-Esteban L., Collado L, Vincent, O. and Escalante, R.

Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, Spain

 

Impairment of autophagy in plasmanylethanolamine desaturase-deficient cells (ID_45)

M. Posada-Gracia1, J. Alarcón-Gil1, M. J. Asensio1, Nogales M.D.C.1, M. J. Casarejos1, E. Bastida-Martínez2, M. Elías-Arnanz2, J.A. Rodríguez-Navarro1,3

1 Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain 2 Departamento de Genética y Microbiología, Área de Genética (Unidad Asociada al Instituto de Química Física “Rocasolano”, Consejo Superior de Investigaciones Científicas), Facultad de Biología, Universidad de Murcia, Murcia 30100, Spain

3Universidad Complutense de Madrid (UCM), departamento de Biología Celular

 

Implication of SIRT1 axis in Queen Bee Acid-induced autophagy (ID_61)

Paredes-Barquero M.1,2,*, Martínez-Chacón G.1,2,3, Alegre-Cortés E.1,2, Canales- Cortés S.1,2, Gimenez-Bejarano A.1,2, Uribe-Carretero E.1,2,3, Sánchez-Molinero L.1,3, Domínguez-Rojo N.1, Blanco-Benítez M.1,3 Gómez-Suaga P.1,2, Yakhine-Diop SMS.2,3, González-Polo RA.1,2,3, Fuentes JM.1,2,3, Niso-Santano M.1,2,3

1Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Spain.

2Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain.

3Centro de Investigación Biomédica en Red de Enfermedades (CIBERNED), Madrid,

Spain.

 

THE PARKINSONIAN LRRK2 R1441G MUTATION SHOWS  MACROAUTOPHAGY-MITOPHAGY DYSREGULATION CONCOMITANT WITH ENDOPLASMIC RETICULUM STRESS

EFFECT OF LRRK2 R1441G MUTATION ON THE MECHANISM OF AUTOPHAGY IN HUMAN CELLS FROM PARKINSON'S PATIENTS (ID_31)

Saray Canales-Cortés1, Mario Rodríguez-Arribas1, Guadalupe Martínez-Chacón1,2,3, Gema Duque González1, Marta Paredes-Barquero1, Eva Alegre-Cortés1, Elisabet Uribe-Carretero1,2,3, Ana Calderón1, Alberto Gimenez-Bejarano1,2, Patricia Gómez Suaga1,2, Mercedes Blanco-Benítez1, Vicente Climent4, Ana Aiastui3,5,8, Adolfo Lopez de Munain3,7,8,9, José M. Bravo-San Pedro3,10, Mireia Niso-Santano1,2,3, José M. Fuentes1,2,3, Sokhna M.S. Yakhine-Diop1,2,3, Rosa A. González-Polo1,2,3.

1 Universidad de Extremadura, Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Cáceres, Spain,

2 Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain,

3 Centro de Univestigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Spain,

4 Universidad de Extremadura, Departmento de Anatomía y Embriología Humana, Facultad de Medicina, Badajoz, Spain,

5 Cell Culture Plataform, Donostia University Hospital, San Sebastián, Spain,

6 Neuroscience Area of Biodonostia Health Research Institute, Donostia University Hospital, San Sebastián, Spain,

7 Donostia University Hospital, Department of Neurology, San Sebastian, Spain,

8 Ilundain Foundation, San Sebastian, Spain,

 9 Department of Neurosciences, University of the Basque Country UPV-EHU, San Sebastián, Spain,

10 Complutense University of Madrid, Faculty of Medicine, Department of physiology, Madrid, Spain

 

Unveiling the role of autophagy in the chloroplast stress response in the model microalga Chlamydomonas reinhardtii (ID_57)

Gámez-Arcas S.1, Heredia-Martínez L. G. 1, Mallén-Ponce M. J.1, Crespo J. L.1 and Pérez-Pérez M. E.1

1Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla, Spain.