Communications
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Oral Communications
Wednesday, March 4th Session 1 16:30h-17:00h Study of 10-H2DA-induced Autophagy (ID_20) Marta Paredes-Barquero1, Guadalupe Martínez-Chacón1,2,3, Elisabet Uribe-Carretero1,2,3, Saray Canales-Cortés1, Eva Alegre-Cortés1, Ana B. Galan-Guerra1,3, Sokhna M.S Yakhine-Diop1,2,3, Rosa A. Gonzalez-Polo1,2,3, José M. Fuentes1,2,3, Mireia Niso-Santano 1 2,3, 1 Depto. Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura Avda de la Universidad s/n, Cáceres, Spain 2 Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) Madrid, Spain 3 Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain. 17:00h-17:30h The mitophagy receptor BNIP3 controls inflammaging by regulating mitochondrial and lysosomal function in skeletal muscle (ID_6) Irazoki A1, Martínez-Vicente M2, Zorzano A1 and Sebastián D1. 1 Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10-12, 08028 Barcelona, Spain; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) 2 Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute-Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), 08035 Barcelona, Spain 18:30h-19:00h Epigenetic signature involved in the therapeutic response of Sorafenib in advanced hepatocellular carcinoma (ID_7) de la Cruz-Ojeda P 1,2, González R 1,3, Navarro-Villarán E 1,3, Negrete M1, Rodríguez-Hernández M.A 1,3, Gómez-Espejo M. I 4, Rojas A1 , Fernández-Luque I. M 4, Domínguez-Borrero M. F 5 , Gómez-Bravo M. A 1,2,3,4, Romero-Gómez 1, 3, 5, 6, Marín L.M 1,2,4, Ferrer M. T 5, Praena-Fernández J. M 7, Padillo F. J 1,2,3,4, Muntané J 1,2,3,4 1Institute of Biomedicine of Seville (IBiS), Hospital University “Virgen del Rocío”/CSIC/University of Seville, Spain. 2Department of Surgery, University of Seville, Seville, Spain 3Biomedical Research Center for Hepatic and Digestive Diseases (CIBEREHD), Madrid, Spain 4Department of General Surgery, Hospital University “Virgen del Rocío”/CSIC/University of Seville/IBIS, Seville, Spain 5Department of Gastroenterology, Hospital University “Virgen del Rocío”/CSIC/University of Seville/IBIS, Seville, Spain 6Department of Medicine, University of Seville, Seville, Spain 7Department of Nursery, CSIC-JA-University of Seville-Institute of Biomedicine of Seville, Seville, Spain. 19:00h-19:30h Dissecting a neuron-to-liver crosstalk to modulate lipid metabolism in Batten disease (ID_8) García-Macia M, Bolaños JP Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca, Institute of Functional Biology and Genomics (IBFG), Salamanca. 19:30h-20:00h Amyloid beta modulates neuronal autophagy through the primary cilium (ID_12) O. Pampliega 1,2,3,4, F.N. Soria 1,2,3,4, N. Pineda-Ramírez5, E. Bézard3,4. 1 Achucarro Basque Center for Neuroscience, Leioa, Spain 2 Universidad del País Vasco UPV/EHU, Leioa, Spain 3 Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France 4 CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France 5 Universidad Nacional Autónoma de Mexico, Mexico DF, Mexico Thursday, March 5th Session 2 10:00h-10:30h New insights on autophagy in the model unicellular green alga Chlamydomonas reinhardtii (ID_27) Pérez-Pérez M. E., Couso I., Heredia-Martínez L. G. and Crespo J. L. Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla. 10:30h-11:00h Activation of papain-like cysteine proteases during programmed cell death of tapetum in barley (ID_30) Pérez-Pérez Y.1, Havé M.2, Díaz I.3, Masclaux-Daubresse C.2, Testillano P.S.1 1Pollen Biotechnology of Crop Plants group, Center of Biological Research Margarita Salas, CIB-CSIC, Madrid, Spain 2INRA-AgroParisTech, Inst. Jean-Pierre Bourgin, UMR 1318, ERL CNRS 3559, Versailles, France 3Center of Plant Biotechnology and Genomics, CBGP, UPM-INIA, Madrid, Spain 11:30h-12:00h Mercury and cadmium induced autophagy in Chlamydomonas reinhardtii associates with changes of lipid metabolism as analyzed by FTIR spectroscopy and mass spectrometry (ID_32) Ángel Barón-Sola1, Flor Martinez1, Margarita Toledo1, Laura Arellano1, Xinyi Liu1, Tanja Ducic2, Ibraheem Yousef2, Cristina Ortega-Villasante1, and Luis E. Hernandez1,* 1Laboratory of Plant Physiology, Department of Biology, Universidad Autónoma de Madrid, Campus Cabtoblanco, 28049 Madrid, Spain 2MIRAS-ALBA Synchrotron Light Source, 08290 Cerdanyola del Vallès, Barcelona, Spain 12:00h-12:30h Characterization of an atg8 mutant by CRISPR/Cas9 in the model microalga Chlamydomonas reinhardtii (ID_25) Heredia-Martínez L. G., Pérez-Pérez M. E. and Crespo J. L. Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla. 12:30h-13:00h Molecular mechanisms and physiological relevance of the interaction between the Atg1 complex and the lipidation machinery (ID_4) Bueno-Arribas M., Escalante R., Vincent O. Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, Spain Session 3 15:30h- 16:00h Lipophagy as a new strategy for the treatment of Parkinson’s disease (ID_14) Alarcon-Gil, J.1; Sierra-Magro, A.1,2; Morales-Garcia J.A. 1,2,3; Sanz-SanCristobal, M. 1,2; Alonso-Gil, S. 1,2; Perez-Castillo, A. 1,2 1 Instituto de Investigaciones Biomédicas (CSIC-UAM), Arturo Duperier, 4. 28029 Madrid, Spain 2 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo, 5, 28031 Madrid, Spain 3 Departamento de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Plaza Ramón y Cajal s/n, 28040 Madrid, Spain 16:00h-16:30h Ether lipids modulate autophagy in a parkin dependent fashion (ID_19) Gaudioso Aa, García-Rozas Pa, Thiele Cc, Kuerschner Lc, Casarejos MJb, Pastor Ob and Rodríguez-Navarro JAa* a: Cellular Neurobiology laboratory, Neurobiology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain b: Neuropharmacology laboratory, Neurobiology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain c: Bonn University, Germany 16:30h-17:00h Therapeutic target of GCase enzyme in Parkinson’s disease with novel pharmacological chaperones (ID_21) A. Navarro-Romero1*, M. Montpeyó1*, M. Albert1, A. Delgado2, I. Fernández1, J. Riera1, E. Cubero2, X. Barril2, A. M. García2, N. Pérez2, M. Martinez-Vicente1 1 Vall d’Hebron Research Institute(VHIR)-CIBERNED-UAB, Barcelona, Spain. 2 Gain Therapeutics, Barcelona, Spain. * Equal contribution 17:30h-18:00h Cell corpse removal is dependent autophagy during retinal neurogenesis (ID_35) Villarejo-Zori, B., Esteban-Martínez, L., Sierra-Filardi, E. and Boya, P. Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain 18:00h-18:30h A possible key target for blocking glioblastoma progression: chaperone-mediated autophagy in pericytes (ID_15) Molina M.L.1,2, Botia M.1,3, Macian F.4, Cuervo A.M5., Martinez S.2and Valdor R.1,3 1Brain Regionalization and Development Gene Unit at Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain 2 Instituto de Neurociencias UMH-CSIC, CIBERSAM of ISCIII, 03550 San Juan de Alicante, Spain; 3 Internal Medicine Department at University of Murcia-Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain 4 Department of Pathology, Albert Einstein College of Medicine, 5. Department of Developmental Molecular Biology; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461 18:30h-19:00h Drug discovery of mitophagy modulators for neurodegenerative diseases (ID_34) Maestro I.,1 de la Ballina L.R.2, Boya P.,1 Simonsen A., 2 Martin-Requero A.1,3 and Martinez A.1,3 1Centro de Investigaciones Biológicas Margarita Salas-CSIC, Ramiro de Maeztu 9, 28004 Madrid (Spain) 2Faculty of Medicine, Institute of Basic Medical Sciences and Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, 1112 Blindern, 0317, Oslo, Norway. 3Centro de Investigación Biomédica en Red en enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid (Spain) Friday, March 6th Session 4 10:00h-10:30h Parkin plays a key role in the control of mitophagy associated with adipose tissue plasticity in response to aging and thermal challenges (ID_33) Villarroya, J.1,2; Delgado-Anglés, A.1,2; Villarroya, F.1,2; Giralt, M.1,2; Cairó, M.1,2 1. Departament de Bioquímica i Biomedicina Molecular. Facultat de Biologia. Universitat de Barcelona. Barcelona. 2. Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición, Madrid. 10:30h-11:00h Mitochondrial diseases modelling using patient-derived induced neurons (ID_38) Povea-Cabello S*, Villanueva-Paz M*, Villalón-García I*, Talaverón-Rey M*, Suárez-Rivero JM*, Álvarez-Córdoba M*, Suárez-Carrillo A*, Munuera-Cabeza M* & Sánchez-Alcázar JA*. *Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain. 11:30h-12:00h ATG4D: From delipidation to neurodegeneration (ID_3) Tamargo-Gómez I., Martínez-García G.G., Fernández A.F., Mariño G. Departamento de Biología Funcional, Universidad de Oviedo and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, SPAIN 12:00h-12:30h The interplay between autophagy and ion transporters (ID_13) Fernández, Á. F. Center for Autophagy Research, University of Texas Southwestern Medical Center (Dallas, Estados Unidos); Fundación para la Investigación y la Innovación Biosanitaria del Principado de Asturias (Oviedo, Asturias). 12:30h-13:00h Microglial Autophagy and Phagocytosis: a tale of two degradation pathways (ID_29) Plaza-Zabala A1,2, Sierra-Torre V1,2, Valero J1,2, Beccari S1,2, Capetillo-Zarate E1,2,3, Carretero-Guillén A1, Crespo-Castrillo A7, Guan JL4, Mariño G5,6, Boya P7, Sierra A1,2,3. 1 Achucarro Basque Center for Neuroscience, 48940 Leioa, Bizkaia, Spain 2 Universidad del País Vasco (UPV/EHU), 48940 Leioa, Bizkaia, Spain 3 Ikerbasque Foundation, 48013 Bilbao, Bizkaia, Spain 4 Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA 5 Instituto de Investigación Sanitaria del Principado de Asturias, 33011, Oviedo, Spain 6 Departamento de Biología Funcional, Universidad de Oviedo, 33011, Oviedo, Spain 7 Centro de Investigaciones Biológicas, CSIC, Madrid, Spain 13:00h-13:30h Unconventional autophagy mediated by ATG16L1 regulates cytokine receptor trafficking and signalling (ID_40) Serramito-Gómez, I; Boada-Romero, E; Villamuera, R; Fernández-Cabrera, A; Cedillo, JL and Pimentel-Muiños, FX Instituto de Biología Molecular y Celular del Cáncer. Centro de Investigación del Cáncer Consejo Superior de Investigaciones Científicas (CSIC) Universidad de Salamanca. Campus Miguel de Unamuno. Salamanca, 37007 13:30h-14:00h A post-ER degradation pathway that depends on non- canonical internalization from the vacuolar membrane (ID_43) Lemus L., Matic Z., Goder V. Department of Genetics. University of Seville. Spain, Seville, Spain.
Poster Communications
A systematic review of autophagy modulation in corneal diseases (ID_16) Martínez-Chacón G*1,2,3,4, Ballestín A4, Vela FJ4, Campos JL4, Abellán E4, Yakhine-Diop S.M.S1,2,3 1Department of Biochemistry and Molecular Biology and Genetics. Faculty of Nursing and Occupational Therapy. University of Extremadura, Cáceres, Spain 2Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain 3Instituto Universitario de Investigación Biosanitaria (INUBE) 4Department of Microsurgery, Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain Alcohol exacerbates inherited cardiomyopathy by an autophagy-related mechanism (ID_42) García-Macia M1, Dhanaseelan T2, Henderson D2, Chaudhry B2, Santos-Ledo A2. 1IBSAL-USAL, University of Salamanca (Spain) 2Bioscence Institute, Newcastle University (UK) ATG4D is the main ATG8 delipidating enzyme in mammalian cells (ID_9) Tamargo-Gómez I., Martínez-García G.G., Fernández A.F., Mariño G. Departamento de Biología Funcional, Universidad de Oviedo and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, SPAIN Autophagy in the ripening of strawberry fruits (ID_31) Sánchez-Vera V1 and Valpuesta V1 1 Departamento de Biología Molecular y Bioquímica. Instituto de Hortofruticultura Subtropical y Mediterránea ‘La Mayora’, Universidad de Málaga-Consejo Superior de Investigaciones Científicas, Málaga, Spain Chaperone-Mediated Autophagy affects MuSCs dynamics during muscle regeneration (ID_22) Ramirez-Pardo I1,2, Flández M1,2, Campanario S12, Isern J12, Cuervo AM3 & Muñoz-Cánoves P12* 1Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. 2 Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), E-08003 Barcelona, Spain 3Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, EEUU. Characterization of Autophagy in Muscle Dystrophies (ID_11) Eva Alegre-Cortés1, Ana B. Galan-Guerra1, Elisabet Uribe-Carretero1,2,3, Marta Paredes-Barquero1, Saray Canales-Cortés1, Guadalupe Martínez-Chacón1,2,3, Mireia Niso-Santano1, 2,3, Rosa A. Gonzalez-Polo1, 2,3, Sokhna M.S Yakhine-Diop1, 2,3, José M. Fuentes1, 2,3 1 Depto. Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura Avda de la Universidad s/n, Cáceres Spain 2 Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) Madrid, Spain 3 Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Cáceres Spain. Chemical chaperone-mediated autophagy modulators in the treatment of retinal diseases (ID_36) Raquel Gómez-Sintes1,2,, Evris Gavathiotis3,4, Ana María Cuervo2,4 and Patricia Boya1 1Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas “Margarita Salas”, CSIC, Madrid, Spain. 2Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 3 Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 4 Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY. Elucidating the role of autophagy in the extremophilic microalga Chlamydomonas urium (ID_26) Pérez-Pérez M. E.1, Martínez-Force E.2 and Crespo J. L. 1 1 Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla. 2 Instituto de la Grasa (CSIC). Sevilla. Establishment of a cellular model for the study of a VPS13A related disease (ID_5) Tornero-Écija A.R., Muñoz-Braceras S.*, Navas, M.A., Vincent O., Escalante R. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain. *Present address: Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Melatonin increases phosphorylation of mTOR and beclin-1 expression in rat pancreatic stellate cells subjected to hipoxia (ID_44) Estarás M., Moreno A., Salido G.M. and González A. Institute of Molecular Pathology Biomarkers, University of Extremadura, Caceres, Spain. Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas (ID_28) Couso I.1, Pérez-Pérez M.E.1, Ford M.M.2, Martínez-Force E. 3, Hicks L.M. 2, Umen J.G. 4 and Crespo J. L. 1 1 Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla. 2 Department of Chemistry (University of North Carolina). Chapel Hill, North Carolina USA. 3 Instituto de la Grasa (CSIC). Sevilla. 4 Donald Danforth Plant Science Center, St. Louis, Missouri USA. Polyamines and plant autophagy (ID_1) Malonda S.1, Poidevin L.1, Dagdas Y.2, and Ferrando A.1 1 Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de Valencia, Valencia, Spain. 2 Gregor Mendel Institute of Molecular Plant Biology GmbH, Vienna, Austria. Processing of phosphoenolpyruvate carboxylase by selective autophagy in Arabidopsis thaliana (ID_10) Ana B Feria1, Guillermo Baena1, Luis Hernández Huertas1, Jacinto Gandullo1, José A Monreal1, Sofía García-Mauriño1 1Departamento de Biología Vegetal y Ecología, Facultad de Biología, Universidad de Sevilla, Avenida Reina Mercedes nº 6, 41012 Seville, Spain Rnd3 absence leads to a mitochondrial impairment and increases the autophagy flux (ID_18) C. Cueto-Ureña1, E. Mocholí2, P. Coffer2, I. Pérez-Roger1 and E. Poch1 1 Departamento de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera- CEU, CEU Universities, Alfara del Patriarca, Valencia. Spain. 2 Center for Molecular Medicine, University Medical Center Utrecht, 3584 Utrecht. The Netherlands. Role of autophagy and ACBP during cardiac hypertrophy development (ID_39) Planavila A., Rupérez C., Kular D., Cairó M., Villarroya J., Villarroya F. Departament de Bioquímica i Biomedicina Molecular. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Barcelona, Spain SS-31 antioxidant reduces ER stress, ROS production and autophagy in Type 2 diabetes (ID_2) Víctor M. Víctor1,2, Aranzazu Martínez de Marañón1, Pedro Díaz-Pozo1, Francesca Iannantuoni1, Francisco Canet1, Zaida Abad-Jiménez1, Sandra López-Domènech1, Rubén Díaz-Rúa1, Eva Sola1, Carlos Morillas1, Milagros Rocha1. 1 Department of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO. 46017. Valencia, Spain. 2Department of Physiology, University of Valencia, 46010, Valencia, Spain. Stimulation of autophagy-mediated cancer cell death as a strategy to fight gliomas (ID_37) Velasco G, López-Valero I, Dávila D, Hernández-Tiedra S, Martínez-Martínez E, González-Martínez J, Moraleda R, Santos A, Gabicagogeascoa E, Castillo-Lluva S, Lorente M. Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University & Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain The antiretroviral drug Rilpivirine alters autophagy in both quiescent and activated human stellate cells: novel targets for treatment of liver fibrosis (ID_23) Lucantoni F1,2, Gruevska A1,2, Moragrega AB1,2, Esplugues JV1,2, Blas-García A1,2,3 and Apostolova N1,2 1 Departamento de Farmacología, Universitat de València, Valencia–CIBERehd (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas), Spain 2 FISABIO (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana),Valencia,Spain 3 Departamento de Fisiología, Universitat de València, Valencia, Spain The redox regulation of the ATG8 lipidation system in yeasts and microalgae (ID_24) Pérez-Pérez M. E. and Crespo J. L. Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla). Sevilla. The role of LC3/GABARAP protein family in macroautophagy (ID_17) N. Iriondo, M.; Varela, Y.; Etxaniz, A.; Goñi F. M.; Montes L. R.; Alonso A. Instituto Biofisika (UPV/EHU, CSIC), Bilbao, Bizkaia Transphagocytic B cells need autophagy to cross-present bacteria antigens (ID_41) R. García-Ferreras1, J. Osuna – Pérez1, G. Ramírez-Santiago1, I.Polo-Picasso, A. Méndez-Pérez1, MJ.Gómez-Sánchez1, M. Iborra Pernichi2, N. Martín Martinez2, Y. R. Carrasco1, E. Veiga - Chacón1 1Centro Nacional de Biotecnología (CNB) – CSIC. Madrid. Madrid 2 Centro de Biología Molecular Severo Ochoa (CBMSO) – CSIC. Madrid. Madrid
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